一种不明的、促肾上腺皮质激素依赖的盐皮质激素维持醛固酮减少症年轻女性高血压的证据。

Evidence for an unidentified, adrenocorticotrophic hormone-dependent mineralocorticoid maintaining hypertension in young women with hypoaldosteronism.

Hoefnagels W H, Drayer J I, Hofman J A, Smals A G, Benraad T J, Kloppenborg P W

Clin Sci Mol Med Suppl. 1978 Dec;4:271s-274s. doi: 10.1042/cs055271s.

Abstract

Pronounced hypoaldosteronism was found in five young women with low-renin hypertension and characteristic features of the mineralocorticoid hypertensive syndrome. 2. There was no overproduction of the mineralocorticoids 11-deoxycorticosterone and 18-OH-11-deoxycorticosterone. 3. Dexamethasone restored blood pressure to normal, decreased body weight, increased plasma potassium, and increased plasma renin activity and aldosterone excretion in all patients. 4. The data suggest overproduction of an unknown adrenocorticotrophic hormone-dependent mineralocorticoid maintaining hypertension in these patients.

摘要

在五名患有低肾素性高血压且具有盐皮质激素性高血压综合征特征的年轻女性中发现了明显的醛固酮减少症。2. 盐皮质激素11-脱氧皮质酮和18-羟基-11-脱氧皮质酮没有过量产生。3. 地塞米松使所有患者的血压恢复正常，体重减轻，血钾升高，血浆肾素活性和醛固酮排泄增加。4. 数据表明，一种未知的促肾上腺皮质激素依赖性盐皮质激素过量产生，维持了这些患者的高血压。