• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

微管理检查点蛋白。

Micromanaging checkpoint proteins.

机构信息

The FIRC Institute of Molecular Oncology (IFOM), Milan, Italy.

Department of Biological Sciences, Virginia Tech, Blacksburg, United States.

出版信息

Elife. 2017 Feb 16;6:e25001. doi: 10.7554/eLife.25001.

DOI:10.7554/eLife.25001
PMID:28206949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5313057/
Abstract

The kinase Mps1, long known to be the 'boss' in mitotic checkpoint signaling, phosphorylates multiple proteins in the checkpoint signaling cascade.

摘要

激酶 Mps1，长期以来一直被认为是有丝分裂检查点信号传导中的“老板”，磷酸化检查点信号级联中的多种蛋白质。

相似文献

1
Micromanaging checkpoint proteins.微管理检查点蛋白。
Elife. 2017 Feb 16;6:e25001. doi: 10.7554/eLife.25001.
2
Regulation of kinetochore recruitment of two essential mitotic spindle checkpoint proteins by Mps1 phosphorylation.Mps1磷酸化对两种重要有丝分裂纺锤体检查点蛋白着丝粒募集的调控。
Mol Biol Cell. 2009 Jan;20(1):10-20. doi: 10.1091/mbc.e08-03-0324. Epub 2008 Oct 15.
3
Kinetochore localization of spindle checkpoint proteins: who controls whom?纺锤体检查点蛋白的动粒定位：谁控制谁？
Mol Biol Cell. 2004 Oct;15(10):4584-96. doi: 10.1091/mbc.e04-01-0051. Epub 2004 Jul 21.
4
Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores.Polo样激酶1产生张力感应3F3/2磷酸表位并调节动粒处纺锤体检查点蛋白的结合。
Curr Biol. 2005 Jun 21;15(12):1078-89. doi: 10.1016/j.cub.2005.05.026.
5
Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores.人源MPS1激酶是着丝粒上CENP-E缺失诱导的有丝分裂停滞所必需的。
Mol Biol Cell. 2003 Apr;14(4):1638-51. doi: 10.1091/mbc.02-05-0074.
6
CELL DIVISION CYCLE. Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling.细胞分裂周期。着丝粒处的 MPS1 和微管之间的竞争调节纺锤体检验点信号。
Science. 2015 Jun 12;348(6240):1264-7. doi: 10.1126/science.aaa4055. Epub 2015 Jun 11.
7
Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores.Plx1是一种3F3/2激酶，负责将纺锤体检查点蛋白靶向至动粒。
J Cell Biol. 2005 Aug 29;170(5):709-19. doi: 10.1083/jcb.200502163.
8
Mph1 kinetochore localization is crucial and upstream in the hierarchy of spindle assembly checkpoint protein recruitment to kinetochores.Mph1 着丝粒定位在上游，对于纺锤体组装检验点蛋白在着丝粒上的募集非常关键。
J Cell Sci. 2012 Oct 15;125(Pt 20):4720-7. doi: 10.1242/jcs.110387. Epub 2012 Jul 23.
9
The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit.有丝分裂检查点：一种信号通路，允许单个未附着的动粒抑制有丝分裂退出。
Prog Cell Cycle Res. 2003;5:431-9.
10
Different spindle checkpoint proteins monitor microtubule attachment and tension at kinetochores in Drosophila cells.不同的纺锤体检查点蛋白监测果蝇细胞中动粒处的微管附着和张力。
J Cell Sci. 2004 Apr 1;117(Pt 9):1757-71. doi: 10.1242/jcs.01033. Epub 2004 Mar 16.

引用本文的文献

1
Structural, enzymatic and spatiotemporal regulation of PP2A-B55 phosphatase in the control of mitosis.PP2A-B55磷酸酶在有丝分裂调控中的结构、酶活性及时空调节
Front Cell Dev Biol. 2022 Aug 29;10:967909. doi: 10.3389/fcell.2022.967909. eCollection 2022.
2
Checkpoint signaling and error correction require regulation of the MPS1 T-loop by PP2A-B56.检查点信号和错误校正需要由 PP2A-B56 调节 MPS1 T 环。
J Cell Biol. 2019 Oct 7;218(10):3188-3199. doi: 10.1083/jcb.201905026. Epub 2019 Sep 11.
3
Phosphatases in Mitosis: Roles and Regulation.

本文引用的文献

1
Basis of catalytic assembly of the mitotic checkpoint complex.有丝分裂检查点复合物催化组装的基础。
Nature. 2017 Feb 23;542(7642):498-502. doi: 10.1038/nature21384. Epub 2017 Jan 19.
2
A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling.一个连续的多靶点Mps1磷酸化级联反应促进纺锤体检查点信号传导。
Elife. 2017 Jan 10;6:e22513. doi: 10.7554/eLife.22513.
3
Generation of a Spindle Checkpoint Arrest from Synthetic Signaling Assemblies.从合成信号组装体产生纺锤体检查点阻滞。
有丝分裂中的磷酸酶：作用与调控。
Biomolecules. 2019 Feb 7;9(2):55. doi: 10.3390/biom9020055.
4
MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling.MAD1 依赖性募集 CDK1-CCNB1 到着丝粒促进纺锤体检验点信号传导。
J Cell Biol. 2019 Apr 1;218(4):1108-1117. doi: 10.1083/jcb.201808015. Epub 2019 Jan 23.
5
Multiple Duties for Spindle Assembly Checkpoint Kinases in Meiosis.纺锤体组装检验点激酶在减数分裂中的多种功能
Front Cell Dev Biol. 2017 Dec 13;5:109. doi: 10.3389/fcell.2017.00109. eCollection 2017.
6
Identification of genes and pathways in nasopharyngeal carcinoma by bioinformatics analysis.通过生物信息学分析鉴定鼻咽癌中的基因和通路
Oncotarget. 2017 Jul 22;8(38):63738-63749. doi: 10.18632/oncotarget.19478. eCollection 2017 Sep 8.
Curr Biol. 2017 Jan 9;27(1):137-143. doi: 10.1016/j.cub.2016.11.014. Epub 2016 Dec 22.
4
Bub3-Bub1 Binding to Spc7/KNL1 Toggles the Spindle Checkpoint Switch by Licensing the Interaction of Bub1 with Mad1-Mad2.Bub3与Bub1结合Spc7/KNL1通过许可Bub1与Mad1-Mad2相互作用来切换纺锤体检查点开关。
Curr Biol. 2016 Oct 10;26(19):2642-2650. doi: 10.1016/j.cub.2016.07.040. Epub 2016 Sep 8.
5
The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics.纺锤体组装检验点信号动力学的分子生物学。
Curr Biol. 2015 Oct 19;25(20):R1002-18. doi: 10.1016/j.cub.2015.08.051.
6
CELL DIVISION CYCLE. Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling.细胞分裂周期。着丝粒处的 MPS1 和微管之间的竞争调节纺锤体检验点信号。
Science. 2015 Jun 12;348(6240):1264-7. doi: 10.1126/science.aaa4055. Epub 2015 Jun 11.
7
CELL DIVISION CYCLE. Kinetochore attachment sensed by competitive Mps1 and microtubule binding to Ndc80C.细胞分裂周期。动粒附着由竞争的 Mps1 感知，微管与 Ndc80C 结合。
Science. 2015 Jun 12;348(6240):1260-4. doi: 10.1126/science.aaa4029.
8
The kinetochore encodes a mechanical switch to disrupt spindle assembly checkpoint signalling.动粒编码一种机械开关，以破坏纺锤体组装检查点信号。
Nat Cell Biol. 2015 Jul;17(7):868-79. doi: 10.1038/ncb3179. Epub 2015 Jun 8.
9
Ultrasensitivity part II: multisite phosphorylation, stoichiometric inhibitors, and positive feedback.超敏感性第二部分：多位点磷酸化、化学计量抑制剂与正反馈
Trends Biochem Sci. 2014 Nov;39(11):556-69. doi: 10.1016/j.tibs.2014.09.003. Epub 2014 Oct 23.
10
Mad1 contribution to spindle assembly checkpoint signalling goes beyond presenting Mad2 at kinetochores.Mad1 对纺锤体组装检验点信号的贡献不仅仅在于将 Mad2 呈递到着丝粒上。
EMBO Rep. 2014 Mar;15(3):291-8. doi: 10.1002/embr.201338114. Epub 2014 Jan 29.