Institute of Next Generation Matter Transformation, College of Chemical Engineering and College of Material Sciences Engineering at Huaqiao University , 668 Jimei Boulevard, Xiamen, Fujian 361021, P. R. China.
Org Lett. 2017 Mar 3;19(5):980-983. doi: 10.1021/acs.orglett.6b03713. Epub 2017 Feb 16.
A Ag-catalyzed phosphorus radical promoted cyclization of cinnamamides to give exclusively 2-phosphinoyl-3H-pyrrolo[1,2-a]indoles derivatives via a 5-endo-trig manner is described. This novel reaction leads to the simultaneous formation of C-C and C-P bonds in one step with excellent chemo- (only 5-endo) and diastereoselectivity (dr >20:1) under mild conditions in moderate to good yields.
Ag 催化的磷自由基促进肉桂酰胺的环化反应，以 5-endo-trig 方式得到高化学选择性（仅 5-endo）和非对映选择性（dr＞20:1）的 2-膦酰基-3H-吡咯并[1,2-a]吲哚衍生物，产率中等至良好。该反应条件温和，在一步反应中同时形成 C-C 和 C-P 键。
