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腹腔镜活体供体右半肝切除术联合使用尸体髂总动脉同种异体移植进行静脉流出道重建:病例报告及文献综述

Laparoscopic living donor right hemihepatectomy with venous outflow reconstruction using cadaveric common iliac artery allograft: Case report and literature review.

作者信息

Li Jiaxin, Huang Jiwei, Wu Hong, Zeng Yong

机构信息

Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.

出版信息

Medicine (Baltimore). 2017 Feb;96(7):e6167. doi: 10.1097/MD.0000000000006167.

Abstract

RATIONALE

With the development of laparoscopic technique, the total laparoscopic living donor right hemihepatectomy (LLDRH) procurement surgery has been successfully performed in many liver transplant centers all over the world, and the number of cases is continuing to increase. We report our case of laparoscopic right graft resection with venous outflow reconstruction using cadaveric common iliac artery allograft in our center and review literatures about total LLDRH surgery.

PATIENT CONCERNS AND DIAGNOSES

A 40-year-old male living donor for right hepatectomy was selected after pretransplant evaluation including laboratory tests, liver volume, anatomy of hepatic vein, artery, portal vein, and bile duct. Living donor liver transplantation surgery was approved by Sichuan Provincial Health Department and the ethics committee of the West China Hospital, Sichuan University.

INTERVENTIONS

Hepatic parenchyma transection was performed by ultrasonic scalpel and Cavitron Ultrasonic Surgical Aspirator (CUSA). Right branch of portal vein, right hepatic artery, right hepatic duct, and right hepatic vein were meticulously dissected. The right hepatic duct was ligated and transected 2 mm far from the bifurcation of common hepatic duct, right hepatic artery, and portal vein were also ligated and transected, the right hepatic vein was transected by laparoscopic linear cutting stapler. The gap between short hepatic veins and right hepatic vein was bridged and reconstructed by cadaveric common iliac artery allograft.

OUTCOMES

The operation time was 480 minutes and warm ischemia time was 4 minutes. Blood loss was 300 mL without blood transfusion. The donor was discharged on postoperative day 7 uneventfully without complications. Literatures about laparoscopic living donor right hemihepatectomy are compared and summarized in table.

LESSONS

The total laparoscopic living donor right hemihepatectomy is technically feasible and safe in some transplant centers which should have rich open living donor liver transplantation experience and skilled laparoscopic techniques. Venous outflow tract reconstruction is necessary if orifice diameter of short hepatic vein is greater than 0.5 cm on the graft cutting surface.

摘要

原理

随着腹腔镜技术的发展,全腹腔镜活体供体右半肝切除术(LLDRH)获取手术已在全球许多肝脏移植中心成功开展,且病例数持续增加。我们报告了在本中心使用尸体髂总动脉同种异体移植物进行腹腔镜右半肝切除并重建静脉流出道的病例,并回顾了有关全LLDRH手术的文献。

患者情况与诊断

一名40岁男性活体供体经包括实验室检查、肝脏体积、肝静脉、动脉、门静脉及胆管解剖等移植前评估后被选作右半肝切除供体。活体供肝移植手术获四川省卫生厅及四川大学华西医院伦理委员会批准。

干预措施

采用超声刀和超声外科吸引器(CUSA)进行肝实质离断。仔细解剖门静脉右支、肝右动脉、肝右管及肝右静脉。肝右管在距肝总管分叉处2毫米处结扎并离断,肝右动脉和门静脉也结扎并离断,肝右静脉用腹腔镜直线切割缝合器离断。用尸体髂总动脉同种异体移植物搭桥并重建肝短静脉与肝右静脉之间的间隙。

结果

手术时间为480分钟,热缺血时间为4分钟。出血量为300毫升,未输血。供体术后第7天顺利出院,无并发症。表中对有关腹腔镜活体供体右半肝切除术的文献进行了比较和总结。

经验教训

在一些具备丰富开放性活体供肝移植经验和熟练腹腔镜技术的移植中心,全腹腔镜活体供体右半肝切除术在技术上是可行且安全的。如果移植物切面上肝短静脉的开口直径大于0.5厘米,则有必要进行静脉流出道重建。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0f4/5319542/096e96a320f7/medi-96-e6167-g001.jpg

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