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使用赫菲斯托斯矫形装置研究神经肌肉电刺激和膳食羽扇豆蛋白补充剂的对策效果,一项随机对照试验。

Using the Hephaistos orthotic device to study countermeasure effectiveness of neuromuscular electrical stimulation and dietary lupin protein supplementation, a randomised controlled trial.

作者信息

Zange Jochen, Schopen Kathrin, Albracht Kirsten, Gerlach Darius A, Frings-Meuthen Petra, Maffiuletti Nicola A, Bloch Wilhelm, Rittweger Jörn

机构信息

Division of Space Physiology, Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.

Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Cologne, Germany.

出版信息

PLoS One. 2017 Feb 16;12(2):e0171562. doi: 10.1371/journal.pone.0171562. eCollection 2017.

Abstract

PURPOSE

The present study investigated whether neuromuscular electrical stimulation for 20 min twice a day with an electrode placed over the soleus muscle and nutritional supplementation with 19 g of protein rich lupin seeds can reduce the loss in volume and strength of the human calf musculature during long term unloading by wearing an orthotic unloading device.

METHODS

Thirteen healthy male subjects (age of 26.4 ± 3.7 years) wore a Hephaistos orthosis one leg for 60 days during all habitual activities. The leg side was randomly chosen for every subject. Six subjects only wore the orthosis as control group, and 7 subjects additionally received the countermeasure consisting of neuromuscular electrical stimulation of the soleus and lateral gastrocnemius muscles and lupin protein supplementation. Twenty-eight days before and on the penultimate day of the intervention cross-sectional images of the calf muscles were taken by magnetic resonance imaging (controls n = 5), and maximum voluntary torque (controls n = 6) of foot plantar flexion was estimated under isometric (extended knee, 90° knee flexion) and isokinetic conditions (extended knee), respectively.

RESULTS

After 58 days of wearing the orthosis the percentage loss of volume in the entire triceps surae muscle of the control subjects (-11.9 ± 4.4%, mean ± standard deviation) was reduced by the countermeasure (-3.5 ± 7.2%, p = 0.032). Wearing the orthosis generally reduced plantar flexion torques values, however, only when testing isometric contraction at 90° knee ankle the countermeasure effected a significantly lower percentage decrease of torque (-9.7 ± 7.2%, mean ± SD) in comparison with controls (-22.3 ± 11.2%, p = 0.032).

CONCLUSION

Unloading of calf musculature by an orthotic device resulted in the expected loss of muscle volume and maximum of plantar flexion torque. Neuromuscular electrical muscle stimulation and lupin protein supplementation could significantly reduce the process of atrophy.

TRIAL REGISTRATION

ClinicalTrials.gov, identifier NCT02698878.

摘要

目的

本研究调查了通过在比目鱼肌上方放置电极,每天两次进行20分钟的神经肌肉电刺激,以及补充19克富含蛋白质的羽扇豆种子,是否能够减少在长期使用矫正卸载装置卸载过程中人体小腿肌肉组织的体积和力量损失。

方法

13名健康男性受试者(年龄26.4±3.7岁)在所有日常活动中,单腿佩戴赫菲斯托斯矫形器60天。每条腿的佩戴侧由每个受试者随机选择。6名受试者仅佩戴矫形器作为对照组,7名受试者额外接受了由比目鱼肌和腓肠外侧肌的神经肌肉电刺激以及羽扇豆蛋白补充组成的对策。在干预前28天和倒数第二天,通过磁共振成像获取小腿肌肉的横截面图像(对照组n = 5),并分别在等长(膝关节伸展、膝关节屈曲90°)和等速条件(膝关节伸展)下估计足跖屈的最大自主扭矩(对照组n = 6)。

结果

佩戴矫形器58天后,对照组受试者整个小腿三头肌的体积损失百分比(-11.9±4.4%,平均值±标准差)通过对策降低(-3.5±7.2%,p = 0.032)。佩戴矫形器通常会降低跖屈扭矩值,然而,仅在测试膝关节屈曲90°时的等长收缩时,与对照组相比(-22.3±11.2%,p = 0.032),对策导致扭矩的百分比下降显著更低(-9.7±7.2%,平均值±标准差)。

结论

矫正装置对小腿肌肉组织的卸载导致了预期的肌肉体积损失和跖屈扭矩最大值下降。神经肌肉电刺激和羽扇豆蛋白补充可显著减少萎缩过程。

试验注册

ClinicalTrials.gov,标识符NCT02698878。

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