Krishna Murali, Kumar G Mohan, Veena S R, Krishnaveni G V, Kumaran Kalyanaraman, Karat Samuel Christaprasad, Coakley Patsy, Osmond Clive, Copeland John R M, Chandak Giriraj, Bhat Dattatray, Varghese Mathew, Prince Martin, Fall Caroline
Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, Mysore, Karnataka, India.
MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.
BMJ Open. 2017 Feb 16;7(2):e012552. doi: 10.1136/bmjopen-2016-012552.
For late-life neurocognitive disorders, as for other late-life chronic diseases, much recent interest has focused on the possible relevance of Developmental Origins of Health and Disease (DOHaD). Programming by undernutrition in utero, followed by overnutrition in adult life may lead to an increased risk, possibly mediated through cardiovascular and metabolic pathways. This study will specifically examine, if lower birth weight is associated with poorer cognitive functioning in late life in a south Indian population.
From 1934 onwards, the birth weight, length and head circumference of all babies born in the CSI Holdsworth Memorial Hospital, Mysore, India, were recorded in obstetric notes. Approximately 800 men and women from the Mysore Birth Records Cohort aged above 55 years, and a reliable informant for each, will be asked to participate in a single cross-sectional baseline assessment for cognitive function, mental health and cardiometabolic disorders. Participants will be assessed for hypertension, type-2 diabetes and coronary heart disease, nutritional status, health behaviours and lifestyles, family living arrangements, economic status, social support and social networks. Additional investigations include blood tests (for diabetes, insulin resistance, dyslipidaemia, anaemia, vitamin B and folate deficiency, hyperhomocysteinemia, renal impairment, thyroid disease and Apolipoprotein E genotype), anthropometry, ECG, blood pressure, spirometry and body composition (bioimpedance). We will develop an analysis plan, first using traditional univariate and multivariable analytical paradigms with independent, dependent and mediating/confounding/interacting variables to test the main hypotheses.
This study has been approved by the research ethics committee of CSI Holdsworth Memorial Hospital. The findings will be disseminated locally and at international meetings, and will be published in open access peer reviewed journals.
对于晚年神经认知障碍，与其他晚年慢性疾病一样，近期人们的许多兴趣都集中在健康与疾病的发育起源（DOHaD）的潜在相关性上。子宫内营养不良编程，随后成年期营养过剩，可能会增加风险，这可能通过心血管和代谢途径介导。本研究将具体考察在印度南部人群中，较低的出生体重是否与晚年较差的认知功能相关。
从1934年起，印度迈索尔的基督教医学协会霍尔兹沃思纪念医院出生的所有婴儿的出生体重、身长和头围都记录在产科病历中。将邀请迈索尔出生记录队列中约800名年龄在55岁以上的男性和女性以及他们各自可靠的信息提供者参加一项关于认知功能、心理健康和心血管代谢疾病的单一横断面基线评估。参与者将接受高血压、2型糖尿病和冠心病、营养状况、健康行为和生活方式、家庭生活安排、经济状况、社会支持和社会网络的评估。额外的调查包括血液检测（用于检测糖尿病、胰岛素抵抗、血脂异常、贫血、维生素B和叶酸缺乏、高同型半胱氨酸血症、肾功能损害、甲状腺疾病和载脂蛋白E基因型）、人体测量、心电图、血压、肺活量测定和身体成分（生物电阻抗）。我们将制定一个分析计划，首先使用传统的单变量和多变量分析范式，结合独立、依赖和中介/混杂/相互作用变量来检验主要假设。
本研究已获得基督教医学协会霍尔兹沃思纪念医院研究伦理委员会的批准。研究结果将在当地和国际会议上传播，并将发表在开放获取的同行评审期刊上。
