• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

含多泡囊乳液神经酰胺的保湿剂：对其在常见皮肤病管理中作用的评估

Multivesicular Emulsion Ceramide-containing Moisturizers: An Evaluation of Their Role in the Management of Common Skin Disorders.

作者信息

Zeichner Joshua A, Del Rosso James Q

机构信息

Department of Dermatology, Mount Sinai Hospital, New York, New York.

出版信息

J Clin Aesthet Dermatol. 2016 Dec;9(12):26-32. Epub 2016 Dec 1.

PMID:28210396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5300724/
Abstract

Proper stratum corneum function plays a pivotal role in maintenance of skin health, and improper function leads to skin disease. The stratum corneum is comprised of corneocytes surrounded by intercelluar lipids including ceramides, free fatty acids, and cholesterol. Ceramide predominant moisturizers have become a mainstay of treatment of skin disease. New technologies for delivery of ceramides include multivesicular emulsions, which deposit ceramides in a timerelease manner for a continuous rather than burst effect. Here, the authors review the available data on the use of multivesicular emulsion ceramide moisturizers in various skin diseases.

摘要

角质层的正常功能对维持皮肤健康起着关键作用，而功能异常则会导致皮肤疾病。角质层由被细胞间脂质（包括神经酰胺、游离脂肪酸和胆固醇）包围的角质形成细胞组成。以神经酰胺为主的保湿剂已成为皮肤病治疗的主要手段。神经酰胺递送的新技术包括多泡乳液，其以定时释放的方式沉积神经酰胺，产生持续而非突发的效果。在此，作者综述了多泡乳液神经酰胺保湿剂在各种皮肤病中应用的现有数据。

相似文献

1
Multivesicular Emulsion Ceramide-containing Moisturizers: An Evaluation of Their Role in the Management of Common Skin Disorders.含多泡囊乳液神经酰胺的保湿剂：对其在常见皮肤病管理中作用的评估
J Clin Aesthet Dermatol. 2016 Dec;9(12):26-32. Epub 2016 Dec 1.
2
Trends in stratum corneum research and the management of dry skin conditions.角质层研究和干燥皮肤状况管理的趋势。
Int J Cosmet Sci. 2003 Apr;25(1-2):63-95. doi: 10.1046/j.1467-2494.2003.00174.x.
3
Human stratum corneum lipid organization as observed by atomic force microscopy on Langmuir-Blodgett films.通过原子力显微镜在朗缪尔-布洛杰特膜上观察到的人体角质层脂质结构。
J Struct Biol. 2007 Jun;158(3):386-400. doi: 10.1016/j.jsb.2006.12.006. Epub 2006 Dec 28.
4
Human epidermal glucosylceramides are major precursors of stratum corneum ceramides.人表皮葡糖神经酰胺是角质层神经酰胺的主要前体。
J Invest Dermatol. 2002 Aug;119(2):416-23. doi: 10.1046/j.1523-1747.2002.01836.x.
5
Repair of acetone- and sodium lauryl sulphate-damaged human skin barrier function using topically applied emulsions containing barrier lipids.使用含有屏障脂质的局部应用乳剂修复丙酮和十二烷基硫酸钠损伤的人体皮肤屏障功能
J Eur Acad Dermatol Venereol. 2002 Nov;16(6):587-94. doi: 10.1046/j.1468-3083.2002.00527.x.
6
Phase behavior of stratum corneum lipid mixtures based on human ceramides: the role of natural and synthetic ceramide 1.基于人神经酰胺的角质层脂质混合物的相行为：天然和合成神经酰胺1的作用
J Invest Dermatol. 2002 Apr;118(4):606-17. doi: 10.1046/j.1523-1747.2002.01706.x.
7
Structure of the skin barrier and its modulation by vesicular formulations.皮肤屏障的结构及其由囊泡制剂的调节作用。
Prog Lipid Res. 2003 Jan;42(1):1-36. doi: 10.1016/s0163-7827(02)00028-0.
8
Phase behavior of stratum corneum lipids in mixed Langmuir-Blodgett monolayers.混合朗缪尔-布洛杰特单分子层中角质层脂质的相行为。
Biophys J. 1996 Sep;71(3):1389-99. doi: 10.1016/S0006-3495(96)79341-4.
9
Infrared spectroscopic study of stratum corneum model membranes prepared from human ceramides, cholesterol, and fatty acids.由人神经酰胺、胆固醇和脂肪酸制备的角质层模型膜的红外光谱研究。
Biophys J. 2007 Apr 15;92(8):2785-95. doi: 10.1529/biophysj.106.094292. Epub 2007 Feb 2.
10
Ceramide profiles of the uninvolved skin in atopic dermatitis and psoriasis are comparable to those of healthy skin.特应性皮炎和银屑病未受累皮肤的神经酰胺谱与健康皮肤的神经酰胺谱相当。
Arch Dermatol Res. 2005 May;296(11):514-21. doi: 10.1007/s00403-005-0551-2. Epub 2005 Apr 1.

引用本文的文献

1
Permeation Protection by Waterproofing Mucosal Membranes.通过黏膜防水实现渗透保护。
Pharmaceutics. 2023 Nov 29;15(12):2698. doi: 10.3390/pharmaceutics15122698.
2
Vehicles for Drug Delivery and Cosmetic Moisturizers: Review and Comparison.药物递送载体与化妆品保湿剂：综述与比较
Pharmaceutics. 2021 Nov 26;13(12):2012. doi: 10.3390/pharmaceutics13122012.
3
The diversity of shedder tests and a novel factor that affects DNA transfer.脱落细胞检测的多样性和影响 DNA 转移的新因素。
Int J Legal Med. 2021 Jul;135(4):1267-1280. doi: 10.1007/s00414-021-02533-y. Epub 2021 Mar 30.
4
An Investigation of the Skin Barrier Restoring Effects of a Cream and Lotion Containing Ceramides in a Multi-vesicular Emulsion in People with Dry, Eczema-Prone, Skin: The RESTORE Study Phase 1.含神经酰胺的多泡囊乳剂乳膏和洗剂对干性、易患湿疹皮肤人群皮肤屏障修复作用的研究：RESTORE研究第1阶段
Dermatol Ther (Heidelb). 2020 Oct;10(5):1031-1041. doi: 10.1007/s13555-020-00426-3. Epub 2020 Jul 15.
5
A Phase II Trial to Assess the Safety and Efficacy of a Topical Repair Cream Containing Skin-identical Ceramide Complex in Patients with Contact Dermatitis.一项评估含皮肤同源神经酰胺复合物的外用修复乳膏治疗接触性皮炎患者安全性和有效性的II期试验。
J Clin Aesthet Dermatol. 2018 Nov;11(11):40-44. Epub 2018 Nov 1.
6
Skin hydration is significantly increased by a cream formulated to mimic the skin's own natural moisturizing systems.一种旨在模仿皮肤自身天然保湿系统的乳霜能显著增加皮肤的水分含量。
Clin Cosmet Investig Dermatol. 2018 Oct 15;11:491-497. doi: 10.2147/CCID.S177697. eCollection 2018.

本文引用的文献

1
Understanding the Epidermal Barrier in Healthy and Compromised Skin: Clinically Relevant Information for the Dermatology Practitioner: Proceedings of an Expert Panel Roundtable Meeting.了解健康及受损皮肤的表皮屏障：皮肤科医生的临床相关信息：专家小组圆桌会议纪要
J Clin Aesthet Dermatol. 2016 Apr;9(4 Suppl 1):S2-S8. Epub 2016 Apr 1.
2
Moisturizers and Ceramide-containing Moisturizers May Offer Concomitant Therapy with Benefits.保湿剂和含神经酰胺的保湿剂可能提供具有益处的联合疗法。
J Clin Aesthet Dermatol. 2014 Mar;7(3):18-26.
3
Barrier-repair prescription moisturizers: do we really need them? Facts and controversies.屏障修复处方保湿剂：我们真的需要它们吗？事实和争议。
Clin Dermatol. 2013 Nov-Dec;31(6):787-91. doi: 10.1016/j.clindermatol.2013.05.018.
4
Acne Vulgaris and the Epidermal Barrier: Is Acne Vulgaris Associated with Inherent Epidermal Abnormalities that Cause Impairment of Barrier Functions? Do Any Topical Acne Therapies Alter the Structural and/or Functional Integrity of the Epidermal Barrier?寻常痤疮与表皮屏障：寻常痤疮是否与导致屏障功能受损的固有表皮异常相关？任何外用痤疮治疗方法是否会改变表皮屏障的结构和/或功能完整性？
J Clin Aesthet Dermatol. 2013 Feb;6(2):18-24.
5
A look at epidermal barrier function in atopic dermatitis: physiologic lipid replacement and the role of ceramides.特应性皮炎的表皮屏障功能研究：生理性脂质替代及神经酰胺的作用
Skin Therapy Lett. 2012 Jul;17(7):6-9.
6
Efficacy and safety of a ceramide containing moisturizer followed by fixed-dose clindamycin phosphate 1.2%/benzoyl peroxide 2.5% gel in the morning in combination with a ceramide containing moisturizer followed by tretinoin 0.05% gel in the evening for the treatment of facial acne vulgaris.
J Drugs Dermatol. 2012 Jun;11(6):748-52.
7
The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin.在健康皮肤和患病皮肤中维持角质层功能完整性的临床意义。
J Clin Aesthet Dermatol. 2011 Sep;4(9):22-42.
8
A Guide to the Ingredients and Potential Benefits of Over-the-Counter Cleansers and Moisturizers for Rosacea Patients.玫瑰痤疮患者非处方洁面产品和保湿产品成分及潜在益处指南。
J Clin Aesthet Dermatol. 2011 Aug;4(8):31-49.
9
An over-the-counter moisturizer is as clinically effective as, and more cost-effective than, prescription barrier creams in the treatment of children with mild-to-moderate atopic dermatitis: a randomized, controlled trial.一项随机对照试验表明：在治疗轻至中度特应性皮炎儿童时，非处方保湿霜在临床效果上与处方屏障乳膏相当，且更具成本效益。
J Drugs Dermatol. 2011 May;10(5):531-7.
10
The use of moisturizers as an integral component of topical therapy for rosacea: clinical results based on the Assessment of Skin Characteristics Study.保湿剂作为酒渣鼻局部治疗的重要组成部分的应用：基于皮肤特征评估研究的临床结果
Cutis. 2009 Aug;84(2):72-6.