Depuydt C E, Beert J, Bosmans E, Salembier G
Department of Clinical and Molecular Pathology, AML, Sonic Healthcare, Antwerp, Belgium.
Department of Clinical and Molecular Pathology, AML, Sonic Healthcare, Antwerp, Belgium; Intermediate structure human body material, AML, Sonic Healthcare, Antwerp, Belgium.
Facts Views Vis Obgyn. 2016 Dec;8(4):211-222.
In the natural history of HPV infections, the HPV virions can induce two different pathways, namely the infec- tious virion producing pathway and the clonal transforming pathway. An overview is given of the burden that is associated with HPV infections that can both lead to cervical cancer and/or temporal subfertility. That HPV infections cause serious global health burden due to HPV-associated cancers is common knowledge, but that it is also responsible for a substantial part of idiopathic subfertility is greatly underestimated. The bulk of the detected HPV DNA whether in men or women is however infectious from origin. Because the dissociation between HPV viruses and HPV virions or infection and disease remains difficult for clinicians as well as for HPV detection, we propose a review of the different effects caused by the two different HPV virion induced pathways, and highlight the mechanisms that are responsible for causing transient subfertility and cancer.
在人乳头瘤病毒（HPV）感染的自然病程中，HPV病毒粒子可诱导两种不同的途径，即产生感染性病毒粒子的途径和克隆转化途径。本文概述了与HPV感染相关的负担，HPV感染既可能导致宫颈癌，也可能导致暂时性生育力低下。HPV感染因相关癌症而造成严重的全球健康负担，这是众所周知的，但它也是特发性生育力低下的重要原因，这一点却被大大低估了。然而，无论在男性还是女性中检测到的大部分HPV DNA本质上都具有传染性。由于HPV病毒与HPV病毒粒子之间的分离，以及感染与疾病之间的关系，对临床医生和HPV检测来说仍然很困难，因此我们建议对两种不同的HPV病毒粒子诱导途径所造成的不同影响进行综述，并强调导致暂时性生育力低下和癌症的机制。
