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疑似肝损伤与因果关系的困境

Suspected Liver Injury and the Dilemma of Causality.

作者信息

Teschke Rolf, Eickhoff Axel

机构信息

Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Hanau, Academic Teaching Hospital of the Medical Faculty, Goethe University Frankfurt/Main, Leimenstrasse 20, 63450, Hanau, Germany.

出版信息

Dig Dis Sci. 2017 Apr;62(4):1095-1098. doi: 10.1007/s10620-016-4442-5. Epub 2017 Feb 16.

DOI:10.1007/s10620-016-4442-5
PMID:28210906
Abstract

For causality assessment in cases of suspected liver injury, RUCAM provides objective and transparent results and should be the preferred tool rather than the DILIN method, which is based on subjective opinion.

摘要

对于疑似肝损伤病例的因果关系评估，RUCAM能提供客观且透明的结果，应成为首选工具，而非基于主观判断的DILIN方法。

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本文引用的文献

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Dig Dis Sci. 2016 Sep;61(9):2741-8. doi: 10.1007/s10620-016-4181-7. Epub 2016 May 3.
2
Drug-Induced Liver Injury: Highlights from a Review of the 2015 Literature.药物性肝损伤：2015年文献综述要点
Drug Saf. 2016 Sep;39(9):801-21. doi: 10.1007/s40264-016-0427-8.
3
Herbal Hepatotoxicity: Clinical Characteristics and Listing Compilation.草药肝毒性：临床特征与列表汇编
药物性肝损伤：生物标志物能否辅助RUCAM进行因果关系评估？
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Int J Mol Sci. 2016 Apr 27;17(5):588. doi: 10.3390/ijms17050588.
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The Honolulu Liver Disease Cluster at the Medical Center: Its Mysteries and Challenges.医学中心的檀香山肝病聚集区：其谜团与挑战。
Int J Mol Sci. 2016 Mar 31;17(4):476. doi: 10.3390/ijms17040476.
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Drug-Induced Liver Injury Network Causality Assessment: Criteria and Experience in the United States.药物性肝损伤网络因果关系评估：美国的标准和经验。
Int J Mol Sci. 2016 Feb 4;17(2):201. doi: 10.3390/ijms17020201.
6
RUCAM in Drug and Herb Induced Liver Injury: The Update.药物及草药所致肝损伤的RUCAM：最新进展
Int J Mol Sci. 2015 Dec 24;17(1):14. doi: 10.3390/ijms17010014.
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The mystery of the Hawaii liver disease cluster in summer 2013: A pragmatic and clinical approach to solve the problem.2013年夏季夏威夷肝病聚集病例之谜：解决该问题的务实临床方法。
Ann Hepatol. 2016 Jan-Feb;15(1):91-109. doi: 10.5604/16652681.1184237.
8
The Role of Adverse Event Reporting in the FDA Response to a Multistate Outbreak of Liver Disease Associated with a Dietary Supplement.不良事件报告在FDA应对与一种膳食补充剂相关的多州肝病暴发中的作用。
Public Health Rep. 2015 Sep-Oct;130(5):526-32. doi: 10.1177/003335491513000515.
9
Causality assessment in drug-induced liver injury using a structured expert opinion process: comparison to the Roussel-Uclaf causality assessment method.药物性肝损伤的因果关系评估：采用结构化专家意见程序与 Roussel-Uclaf 因果关系评估方法的比较。
Hepatology. 2010 Jun;51(6):2117-26. doi: 10.1002/hep.23577.
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Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex.特异质性药物性肝损伤的表型特征：年龄和性别的影响。
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