Huang Rong, Tian Sai, Cai Rongrong, Sun Jie, Xia Wenqing, Dong Xue, Shen Yanjue, Wang Shaohua
Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
J Cell Mol Med. 2017 Aug;21(8):1448-1456. doi: 10.1111/jcmm.13079. Epub 2017 Feb 17.
Saitohin (STH) Q7R polymorphism has been reported to influence the individual's susceptibility to Alzheimer's disease (AD); however, conclusions remain controversial. Therefore, we performed this meta-analysis to explore the association between STH Q7R polymorphism and AD risk. Systematic literature searches were performed in the PubMed, Embase, Cochrane Library and Web of Science for studies published before 31 August 2016. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of the association using a fixed- or random-effects model. Subgroup analyses, Galbraith plot and sensitivity analyses were also performed. All statistical analyses were performed with STATA Version 12.0. A total of 19 case-control studies from 17 publications with 4387 cases and 3972 controls were included in our meta-analysis. The results showed that the Q7R polymorphism was significantly associated with an increased risk of AD in a recessive model (RR versus QQ+QR, OR = 1.27, 95% CI = 1.01-1.60, P = 0.040). After excluding the four studies not carried out in caucasians, the overall association was unchanged in all comparison models. Further subgroup analyses stratified by the time of AD onset, and the quality of included studies provided statistical evidence of significant increased risk of AD in RR versus QQ+QR model only in late-onset subjects (OR = 1.56, 95% CI = 1.07-2.26, P = 0.021) and in studies with high quality (OR = 1.37, 95% CI = 1.01-1.86, P = 0.043). This meta-analysis suggests that the RR genotype in saitohin Q7R polymorphism may be a human-specific risk factor for AD, especially among late-onset AD subjects and caucasian populations.
据报道，Saitohin（STH）Q7R多态性会影响个体患阿尔茨海默病（AD）的易感性；然而，结论仍存在争议。因此，我们进行了这项荟萃分析，以探讨STH Q7R多态性与AD风险之间的关联。我们在PubMed、Embase、Cochrane图书馆和科学网中对2016年8月31日前发表的研究进行了系统的文献检索。使用固定效应或随机效应模型计算合并比值比（OR）和95%置信区间（CI），以评估关联强度。我们还进行了亚组分析、Galbraith图分析和敏感性分析。所有统计分析均使用STATA 12.0版软件进行。我们的荟萃分析共纳入了17篇出版物中的19项病例对照研究，包括4387例病例和3972例对照。结果显示，在隐性模型中（RR与QQ + QR相比），Q7R多态性与AD风险增加显著相关（OR = 1.27，95% CI = 1.01 - 1.60，P = 0.040）。在排除四项非针对高加索人群开展的研究后，在所有比较模型中总体关联不变。进一步按AD发病时间进行亚组分析，以及根据纳入研究的质量进行分析，结果表明，仅在晚发型受试者（OR = 1.56，95% CI = 1.07 - 2.26，P = 0.021）和高质量研究（OR = 1.37，95% CI = 1.01 - 1.86，P = 0.043）中，RR与QQ + QR模型相比，有统计学证据表明AD风险显著增加。这项荟萃分析表明，saitohin Q7R多态性中的RR基因型可能是AD的一种人类特异性风险因素，尤其是在晚发型AD受试者和高加索人群中。
