Allaert François-André, Villet Stéphanie, Vincent Stéphane, Sauve Laurent
Ceren Esc, Dijon, France.
Department of Medical Information, CHU Dijon, France.
Minerva Pediatr. 2018 Apr;70(2):117-126. doi: 10.23736/S0026-4946.17.04752-1. Epub 2017 Feb 17.
Over-the-counter medicines may be proposed by pharmacists for children with acute cough. Study objectives were to describe the sociodemographic profile of children who were proposed a cough syrup by a pharmacist, the nature of the cough and type(s) of cough syrup proposed and to assess the evolution of the cough, tolerance and satisfaction with treatment.
Observational, prospective, longitudinal, multicentre study with 157 pharmacies in France. Children who were proposed a cough syrup by a pharmacist were recruited. Questionnaires were completed by the pharmacists and/or parents at inclusion and by the parents after 5 days of treatment.
Four hundred fourteen children were included (mean age: 6.0±2.9 years); 45.9% had a dry and 43.3% a productive cough. 30.4% were proposed an allopathic antitussive syrup, 28.3% an allopathic expectorant syrup and 23.7% a homeopathic syrup. Children with a dry cough were more likely to be given an allopathic antitussive (55.2%) or homeopathic (28.2%) syrup. Children with a productive cough or cough of several days duration were more likely to be given an allopathic expectorant syrup (70.1%). Cough disappearance was more frequent with homeopathic syrups compared to allopathic expectorants (P=0.002), or allopathic antitussives (P=0.042). Adverse events were most common with allopathic antitussive syrups (18.7%) (P<0.001). Two-thirds of parents were satisfied with the treatment their child received.
Pharmacists play an important role in the management of acute cough in children. Homeopathic cough syrups may have an interest in terms of public health.
药剂师可能会为患有急性咳嗽的儿童推荐非处方药。研究目的是描述被药剂师推荐止咳糖浆的儿童的社会人口统计学特征、咳嗽的性质和所推荐止咳糖浆的类型，并评估咳嗽的演变、耐受性和对治疗的满意度。
在法国的157家药店进行观察性、前瞻性、纵向、多中心研究。招募被药剂师推荐止咳糖浆的儿童。在纳入时由药剂师和/或家长填写问卷，并在治疗5天后由家长填写问卷。
纳入414名儿童（平均年龄：6.0±2.9岁）；45.9%为干咳，43.3%为湿性咳嗽。30.4%被推荐使用对抗疗法止咳糖浆，28.3%被推荐使用对抗疗法祛痰糖浆，23.7%被推荐使用顺势疗法糖浆。干咳儿童更有可能被给予对抗疗法止咳糖浆（55.2%）或顺势疗法糖浆（28.2%）。湿性咳嗽或咳嗽持续数天的儿童更有可能被给予对抗疗法祛痰糖浆（70.1%）。与对抗疗法祛痰糖浆（P=0.002）或对抗疗法止咳糖浆（P=0.042）相比，顺势疗法糖浆使咳嗽消失更为常见。对抗疗法止咳糖浆的不良事件最为常见（18.7%）（P<0.001）。三分之二的家长对其孩子接受的治疗感到满意。
药剂师在儿童急性咳嗽的管理中发挥着重要作用。顺势疗法止咳糖浆在公共卫生方面可能具有意义。
