He Ya-Ping, Xu Hui-Xiong, Li Xiao-Long, Li Dan-Dan, Bo Xiao-Wan, Zhao Chong-Ke, Liu Bo-Ji, Wang Dan, Xu Hui-Xiong
Clin Hemorheol Microcirc. 2017;66(1):15-26. doi: 10.3233/CH-16217.
The aim of this study was to compare the diagnostic performance of two different 2D shear wave speed imaging techniques of Virtual Touch Tissue Imaging & Quantification (VTIQ) and Toshiba shear wave elastography (T-SWE) in predicting malignant thyroid nodules (TNs).
75 TNs in 75 patients which were subject to both VTIQ and T-SWE examinations were enrolled and analyzed. Shear wave speed (SWS) values on VTIQ and T-SWE were computed (SWS_max, min, mean and median). Area under the receiver operating characteristic (AUROC) curve was obtained to assess the diagnostic performance.
The AUROC for VTIQ was the highest with SWS_min whereas for T-SWE was SWS_max (0.774 versus 0.851; p > 0.05). The AUROC, sensitivity and negative predictive value (NPV) corresponding to SWS_max for VTIQ were significantly lower than those for T-SWE (0.717 versus 0.851, 61.5% versus 92.3% and 78.7% versus 94.3%; all p < 0.05). However, no significant differences were found between AUROC with SWS_min, SWS_mean, or SWS_median for VTIQ and SWS_max for T-SWE (all p > 0.05).
In general, VTIQ is equal to T-SWE for diagnosis of TNs. In the clinical practice, the selection of SWS_max should be avoided in VTIQ whereas should be selected in T-SWE.
本研究旨在比较虚拟触诊组织成像与定量分析（VTIQ）和东芝剪切波弹性成像（T-SWE）这两种不同的二维剪切波速度成像技术在预测甲状腺恶性结节（TNs）方面的诊断性能。
纳入并分析了75例接受VTIQ和T-SWE检查的患者的75个TNs。计算VTIQ和T-SWE上的剪切波速度（SWS）值（SWS_max、min、mean和median）。获得受试者操作特征（AUROC）曲线下面积以评估诊断性能。
VTIQ以SWS_min时的AUROC最高，而T-SWE以SWS_max时的AUROC最高（0.774对0.851；p>0.05）。VTIQ中与SWS_max对应的AUROC、敏感性和阴性预测值（NPV）显著低于T-SWE（0.717对0.851、61.5%对92.3%和78.7%对94.3%；所有p<0.05）。然而，VTIQ中SWS_min、SWS_mean或SWS_median时的AUROC与T-SWE中SWS_max时的AUROC之间未发现显著差异（所有p>0.05）。
总体而言，VTIQ在诊断TNs方面与T-SWE相当。在临床实践中，VTIQ应避免选择SWS_max，而T-SWE应选择SWS_max。
