[高催乳素血症女性促甲状腺激素升高的频率]

[Frequency of increased thyrotropin in women with hyperprolactinemia].

作者信息

Carranza-Lira Sebastián, Daza-Carrasco María Luisa, Chán-Verdugo Rosario

机构信息

División de Investigación en Salud, Hospital de Ginecoobstetricia 4 "Luis Castelazo Ayala", Instituto Mexicano del Seguro Social, Ciudad de México, México.

出版信息

Rev Med Inst Mex Seguro Soc. 2017;55 Suppl 1:S53-S57.

PMID:28212475

Abstract

BACKGROUND

Hypothyroidism has been associated to hyperprolactinemia. The aim was to establish the frequency of high thyrotropin (TSH) levels in women with hyperprolactinemia.

METHODS

Retrospective, observational, open, and non-controlled study, which included all the non-pregnant women whose prolactin (PRL) and TSH levels were measured between January 1 and December 31, 2014.

RESULTS

437 women were studied. The most frequent diagnoses that motivated PRL measurement were: infertility (31.7%), polycystic ovary syndrome (18.7%), and amenorrhea (7.8%). In the whole group TSH levels were 2.5 ± 2.7 µUl/mL and those of PRL 16.5 ± 13.2 ng/dL. From the total of women, those with normal PRL levels, 1.4% had low TSH levels, 76.6% normal and 7.5% high, while in those with high PRL levels 0.7% had low TSH levels 12.6% normal and 1.1% high. Of those 374 patients with normal PRL, 6 (1.6%) had low TSH levels, 335 (89.6%) normal TSH levels, and 33 (8.8%) high TSH levels. Of those 63 patients with high PRL, 3 (4.8%) had low TSH levels, 55 (87.3%) normal TSH and 5 (7.9%) high TSH levels.

CONCLUSION

In this study it was not possible to document that the proportion of patients with high TSH was greater in those with hyperprolactinemia.

摘要

背景

甲状腺功能减退与高催乳素血症有关。目的是确定高催乳素血症女性中促甲状腺激素（TSH）水平升高的频率。

方法

回顾性、观察性、开放性和非对照研究，纳入了2014年1月1日至12月31日期间测量催乳素（PRL）和TSH水平的所有非妊娠女性。

结果

共研究了437名女性。促使进行PRL测量的最常见诊断为：不孕症（31.7%）、多囊卵巢综合征（18.7%）和闭经（7.8%）。在整个研究组中，TSH水平为2.5±2.7µUl/mL，PRL水平为16.5±13.2ng/dL。在所有女性中，PRL水平正常者，1.4%的TSH水平低，76.6%正常，7.5%高；而PRL水平高者，0.7%的TSH水平低，12.6%正常，1.1%高。在374名PRL正常的患者中，6名（1.6%）TSH水平低，335名（89.6%）TSH水平正常，33名（8.8%）TSH水平高。在63名PRL高的患者中，3名（4.8%）TSH水平低，55名（87.3%）TSH水平正常，5名（7.9%）TSH水平高。