Carranza-Lira Sebastián, Daza-Carrasco María Luisa, Chán-Verdugo Rosario
División de Investigación en Salud, Hospital de Ginecoobstetricia 4 "Luis Castelazo Ayala", Instituto Mexicano del Seguro Social, Ciudad de México, México.
Rev Med Inst Mex Seguro Soc. 2017;55 Suppl 1:S53-S57.
Hypothyroidism has been associated to hyperprolactinemia. The aim was to establish the frequency of high thyrotropin (TSH) levels in women with hyperprolactinemia.
Retrospective, observational, open, and non-controlled study, which included all the non-pregnant women whose prolactin (PRL) and TSH levels were measured between January 1 and December 31, 2014.
437 women were studied. The most frequent diagnoses that motivated PRL measurement were: infertility (31.7%), polycystic ovary syndrome (18.7%), and amenorrhea (7.8%). In the whole group TSH levels were 2.5 ± 2.7 µUl/mL and those of PRL 16.5 ± 13.2 ng/dL. From the total of women, those with normal PRL levels, 1.4% had low TSH levels, 76.6% normal and 7.5% high, while in those with high PRL levels 0.7% had low TSH levels 12.6% normal and 1.1% high. Of those 374 patients with normal PRL, 6 (1.6%) had low TSH levels, 335 (89.6%) normal TSH levels, and 33 (8.8%) high TSH levels. Of those 63 patients with high PRL, 3 (4.8%) had low TSH levels, 55 (87.3%) normal TSH and 5 (7.9%) high TSH levels.
In this study it was not possible to document that the proportion of patients with high TSH was greater in those with hyperprolactinemia.
甲状腺功能减退与高催乳素血症有关。目的是确定高催乳素血症女性中促甲状腺激素（TSH）水平升高的频率。
回顾性、观察性、开放性和非对照研究，纳入了2014年1月1日至12月31日期间测量催乳素（PRL）和TSH水平的所有非妊娠女性。
共研究了437名女性。促使进行PRL测量的最常见诊断为：不孕症（31.7%）、多囊卵巢综合征（18.7%）和闭经（7.8%）。在整个研究组中，TSH水平为2.5±2.7µUl/mL，PRL水平为16.5±13.2ng/dL。在所有女性中，PRL水平正常者，1.4%的TSH水平低，76.6%正常，7.5%高；而PRL水平高者，0.7%的TSH水平低，12.6%正常，1.1%高。在374名PRL正常的患者中，6名（1.6%）TSH水平低，335名（89.6%）TSH水平正常，33名（8.8%）TSH水平高。在63名PRL高的患者中，3名（4.8%）TSH水平低，55名（87.3%）TSH水平正常，5名（7.9%）TSH水平高。
在本研究中，无法证明高催乳素血症患者中TSH水平高的患者比例更高。
