Schmidt J B, Schurz B, Huber J, Spona J
II. Universitäts-Hautklinik Wien.
Z Hautkr. 1989 Jan 15;64(1):9-12.
31 female patients suffering from androgentic alopecia were examined by means of the TRH test with regard to hypothyroidism and hyperprolactinemia. Before, as well as 20 and 40 minutes after, application of thyroxine releasing hormone (TRH), the serum concentrations of the hypohyseal thyroxine stimulating hormone (TSH) and prolactin (PRL) were measured by radioimmunoassay (RIA). In 7 of the patients (23%), we found increased TSH levels after stimulation with TRH--indicative of hypothyroidism. In 9 of the patients (29%), we observed increased PRL levels after TRH stimulation, indicating prolactinemia. TSH and PRL can interact with androgen metabolism at various levels. Thyroxine may influence the unbound, metabolically active testosterone via the sex hormone binding globulin (SHBG). Prolactine, which is stimulated by TRH, promotes the suprarenal cortisol and androgen production. In 48% of the patients, we found either hypothyroidism or hyperprolactinemia. This suggests that both conditions may contribute to the clinical picture of female androgenetic alopecia, as they interfere with the androgen metabolism.
对31名患有雄激素性脱发的女性患者进行了促甲状腺激素释放激素（TRH）试验，以检查甲状腺功能减退和高泌乳素血症。在应用促甲状腺激素释放激素（TRH）之前以及之后20分钟和40分钟，通过放射免疫分析法（RIA）测量垂体促甲状腺激素（TSH）和催乳素（PRL）的血清浓度。在7名患者（23%）中，我们发现TRH刺激后TSH水平升高，提示甲状腺功能减退。在9名患者（29%）中，我们观察到TRH刺激后PRL水平升高，表明存在高泌乳素血症。TSH和PRL可在多个水平与雄激素代谢相互作用。甲状腺素可能通过性激素结合球蛋白（SHBG）影响未结合的、具有代谢活性的睾酮。由TRH刺激产生的催乳素会促进肾上腺皮质醇和雄激素的生成。在48%的患者中，我们发现了甲状腺功能减退或高泌乳素血症。这表明这两种情况可能都与女性雄激素性脱发的临床表现有关，因为它们会干扰雄激素代谢。
