Candi Eleonora, Smirnov Artem, Panatta Emanuele, Lena Anna Maria, Novelli Flavia, Mancini Mara, Viticchiè Giuditta, Piro Maria Cristina, Di Daniele Nicola, Annicchiarico-Petruzzelli Margherita, Melino Gerry
Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy; IDI-IRCCS "Istituto Dermopatico dell'Immacolata", Biochemistry Laboratory, Rome, Italy.
Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy.
Biochem Biophys Res Commun. 2017 Jan 15;482(3):440-444. doi: 10.1016/j.bbrc.2016.10.094. Epub 2017 Feb 3.
The transcription factor p63 belongs to the p53-family and is a master regulator of proliferative potential, lineage specification, and differentiation in epithelia during development and tissue homeostasis. In cancer, p63 contribution is isoform-specific, with both oncogenic and tumour suppressive roles attributed, for ΔNp63 and TAp63, respectively. Recently, p53 and TAp73, in line with other tumour suppressor genes, have emerged as important regulators of energy metabolism and metabolic reprogramming in cancer. To date, p63 contributions in controlling energy metabolism have been partially investigated; given the extensive interaction of the p53 family members, these studies have potential implications in tumour cells for metabolic reprogramming. Here, we review the role of p63 isoforms, TAp63 and ΔNp63, in controlling cell metabolism, focusing on their specific metabolic target genes and their physiological/functional context of action.
转录因子p63属于p53家族，是发育和组织稳态过程中上皮细胞增殖潜能、谱系特化和分化的主要调节因子。在癌症中，p63的作用具有亚型特异性，分别赋予ΔNp63和TAp63致癌和肿瘤抑制作用。最近，与其他肿瘤抑制基因一样，p53和TAp73已成为癌症中能量代谢和代谢重编程的重要调节因子。迄今为止，p63在控制能量代谢方面的作用已得到部分研究；鉴于p53家族成员之间广泛的相互作用，这些研究对肿瘤细胞的代谢重编程具有潜在影响。在这里，我们综述了p63亚型TAp63和ΔNp63在控制细胞代谢中的作用，重点关注它们的特定代谢靶基因及其生理/功能作用背景。
