Chernesky C E, Rodman J S, Reckler J, Rotterdam H, Marion D, Boolbol J, Vaughan E D
Department of Surgery, Cornell University Medical College, New York, New York.
J Urol. 1987 Oct;138(4):893-4. doi: 10.1016/s0022-5347(17)43410-0.
Irrigation of the urinary tract with alkaline solutions may be used appropriately in some clinical situations to dissolve uric acid stones. Since in vitro studies have suggested that tham-E (pH 10.6) is somewhat more effective than tham (pH 8.6) in promoting dissolution of uric acid, these studies were undertaken to assess the relative toxicities of these two irrigating solutions to the urothelium. Rabbit bladders were irrigated antegrade via a ureterotomy for twenty hours. Tham E produced considerably more mucosal injury than did tham (p = 0.0001). The minimal advantage in rapidity of stone dissolution offered by tham E over tham is more than offset by the considerably increased potential for toxic side effects. The results suggest tham and not tham E should be used for irrigation to dissolve uric acid stones.
在某些临床情况下，可适当使用碱性溶液冲洗尿路以溶解尿酸结石。由于体外研究表明，撒莫-E（pH 10.6）在促进尿酸溶解方面比撒莫（pH 8.6）稍有效，因此进行了这些研究以评估这两种冲洗液对尿路上皮的相对毒性。通过输尿管切开术对兔膀胱进行顺行冲洗20小时。撒莫-E造成的黏膜损伤比撒莫严重得多（p = 0.0001）。撒莫-E在结石溶解速度上比撒莫的微小优势，被其毒性副作用显著增加的可能性所抵消。结果表明，应使用撒莫而非撒莫-E来冲洗以溶解尿酸结石。
