Reckler J, Rodman J S, Jacobs D, Rotterdam H, Marion D, Vaughan E D
J Urol. 1986 Jul;136(1):181-3. doi: 10.1016/s0022-5347(17)44767-7.
Different irrigating solutions are used clinically to dissolve uric acid, cystine and struvite stones. These studies were undertaken to assess the toxicity to the rabbit bladder epithelium of several commonly used formulations. Test solutions were infused antegrade through a left ureterotomy overnight. Bladders were removed and routine histological sections made. A pH 7.6 solution of NaHCO3 appeared harmless. The same solution with two per cent acetylcysteine produced slight injury. All pH 4 solutions caused significant damage to the urothelium. Hemiacidrin, which contains magnesium, produced less damage than did other pH 4 solutions without that cation. Our data tend to support Suby's conclusions that addition of magnesium reduces urothelial injury even though the presence of magnesium will slow dissolution of struvite.
临床上使用不同的冲洗液来溶解尿酸、胱氨酸和鸟粪石结石。进行这些研究是为了评估几种常用配方对兔膀胱上皮的毒性。通过左侧输尿管切开术将测试溶液顺行灌注过夜。取出膀胱并制作常规组织切片。pH 7.6的碳酸氢钠溶液似乎无害。含有2%乙酰半胱氨酸的相同溶液造成了轻微损伤。所有pH 4的溶液均对尿路上皮造成了显著损伤。含镁的半胱氨酸溶液造成的损伤比不含该阳离子的其他pH 4溶液要小。我们的数据倾向于支持苏比的结论，即添加镁可减少尿路上皮损伤，尽管镁的存在会减缓鸟粪石的溶解。
