Bednarska Natalia G, Wren Brendan W, Willcocks Sam J
London School of Hygiene and Tropical Medicine, Keppel Street, London, UK.
London School of Hygiene and Tropical Medicine, Keppel Street, London, UK.
Drug Discov Today. 2017 Jun;22(6):919-926. doi: 10.1016/j.drudis.2017.02.001. Epub 2017 Feb 16.
Glycosylation is one of the most prevalent post-translational modifications of a protein, with a defining impact on its structure and function. Many of the proteins involved in the innate or adaptive immune response, including cytokines, chemokines, and antimicrobial peptides (AMPs), are glycosylated, contributing to their myriad activities. The current availability of synthetic coupling and glycoengineering technology makes it possible to customise the most beneficial glycan modifications for improved AMP stability, microbicidal potency, pathogen specificity, tissue or cell targeting, and immunomodulation.
糖基化是蛋白质最普遍的翻译后修饰之一，对其结构和功能具有决定性影响。许多参与先天或适应性免疫反应的蛋白质，包括细胞因子、趋化因子和抗菌肽（AMPs），都是糖基化的，这有助于它们发挥多种活性。目前合成偶联和糖基工程技术的可用性使得定制最有益的聚糖修饰成为可能，以提高抗菌肽的稳定性、杀菌效力、病原体特异性、组织或细胞靶向性以及免疫调节作用。
