Clark Adrian J L, Chan Li F
Centre for EndocrinologyWilliam Harvey Research Institute, Barts & the London School of Medicine & Dentistry, Queen Mary University of London, Charterhouse Square, London, UK
Centre for EndocrinologyWilliam Harvey Research Institute, Barts & the London School of Medicine & Dentistry, Queen Mary University of London, Charterhouse Square, London, UK.
J Mol Endocrinol. 2017 Apr;58(3):F1-F4. doi: 10.1530/JME-17-0002. Epub 2017 Feb 17.
The melanocortin 2 receptor accessory protein (MRAP) was originally discovered to be an essential co-receptor for the ACTH receptor/melanocortin 2 receptor, and it physically interacts with this receptor and is required for receptor trafficking and ligand binding. A related molecule, MRAP2, is mainly expressed in the CNS and appears to have a role with the melanocortin 4 receptor. Consistent with this is the observation that a massively obese phenotype develops when the gene is deleted in mice. However, the characteristics of this phenotype differ from those of -deleted mice and suggest that an additional role, possibly resulting from an interaction with other receptors is possible. In support of this, a functional interaction with the prokineticin receptors was recently reported. Evidence for other receptor interactions and aspects of the tissue distribution of MRAP and MRAP2 gene expression may indicate that these accessory proteins have a wider role than with the melanocortin receptors alone.
促黑素皮质素2受体辅助蛋白（MRAP）最初被发现是促肾上腺皮质激素受体/促黑素皮质素2受体必不可少的共同受体，它与该受体发生物理相互作用，是受体转运和配体结合所必需的。一种相关分子MRAP2主要在中枢神经系统中表达，似乎与促黑素皮质素4受体有关。与此相符的是，当该基因在小鼠中缺失时会出现严重肥胖的表型。然而，这种表型的特征与促黑素皮质素4受体缺失的小鼠不同，这表明可能存在与其他受体相互作用产生的额外作用。支持这一点的是，最近有报道称它与促动力蛋白受体存在功能相互作用。关于其他受体相互作用以及MRAP和MRAP2基因表达的组织分布情况的证据可能表明，这些辅助蛋白的作用范围比仅与促黑素皮质素受体的作用更广泛。
