Courtney Jo-Maree, Spafford Patricia L
NHMRC Centre of Research Excellence for Chronic Respiratory Disease and Lung Aging, School of Medicine, University of Tasmania, Hobart, TAS, Australia.
Cells Tissues Organs. 2017;203(2):99-104. doi: 10.1159/000450919. Epub 2017 Feb 20.
Chronic obstructive pulmonary disease (COPD) is a major cause of mortality worldwide, and there is currently no treatment that can halt the progression of the disease. Over the last decade there has been increasing interest in the idea that epithelial-mesenchymal transition (EMT) may be active in COPD. Here we review the evidence for EMT in COPD as well as the current progress being made on understanding the drivers and mechanisms involved. Finally, we discuss the potential benefits that understanding EMT may bring to the field of chronic respiratory disease.
慢性阻塞性肺疾病（COPD）是全球范围内主要的死亡原因，目前尚无能够阻止该疾病进展的治疗方法。在过去十年中，上皮-间质转化（EMT）可能在COPD中活跃这一观点越来越受到关注。在此，我们综述了COPD中EMT的证据以及在理解其驱动因素和相关机制方面的当前进展。最后，我们讨论了理解EMT可能给慢性呼吸系统疾病领域带来的潜在益处。
