Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Sleep Med. 2017 Feb;30:185-188. doi: 10.1016/j.sleep.2016.10.013. Epub 2016 Nov 18.
Previous neuroimaging studies have shown subtle structural changes of the brain in various sleep disorders, suggesting detrimental effects of disrupted sleep-wake cycle on brain structures. We aimed to identify structural changes in shift workers relative to day workers. We hypothesized that brain structures belonging to sleep-wake modulation may be altered in shift workers.
Nineteen male shift workers (median age, 21 years) and 19 male day workers (median age, 21 years) voluntarily participated in the current study. Sleep questionnaires were obtained from all participants and compared between the groups. Voxel-based morphometry was used to compare regional gray matter volume between shift workers and day workers (corrected p < 0.05 with small volume correction). Separate correlation analyses were performed between regional gray matter volume change and scores of Epworth Sleepiness Scale and Pittsburgh Sleep Quality Index (Pearson's correlation, p < 0.05).
Compared to day workers, shift workers had higher scores of Beck Depression Inventory-II, Epworth Sleepiness Scale, and Pittsburgh Sleep Quality Index. Compared to day workers, shift workers had a significant gray matter volume reduction in the pontomesencephalic tegmentum. Regional volume of the pontomesencephalic tegmentum negatively correlated with Pittsburgh Sleep Quality Index global score.
We observed that pontomesencephalic tegmentum volume was reduced in shift workers compared to day workers and that the smaller pontomesencephalic tegmentum volume was related to the poorer sleep quality. Our preliminary findings may be related to chronic disruption of circadian rhythm or decreased exposure to bright light in shift workers.
先前的神经影像学研究表明，各种睡眠障碍存在大脑结构的细微变化，这表明睡眠-觉醒周期紊乱对大脑结构有不良影响。我们旨在确定轮班工人与白班工人之间的结构变化。我们假设，睡眠-觉醒调节的脑结构可能在轮班工人中发生改变。
19 名男性轮班工人（中位年龄，21 岁）和 19 名男性白班工人（中位年龄，21 岁）自愿参加了本研究。从所有参与者中获得睡眠问卷，并在组间进行比较。基于体素的形态测量学用于比较轮班工人和白班工人之间的区域灰质体积（校正后的 p 值 < 0.05，小体积校正）。分别对区域灰质体积变化与 Epworth 嗜睡量表和匹兹堡睡眠质量指数（Pearson 相关，p < 0.05）评分之间进行相关性分析。
与白班工人相比，轮班工人的贝克抑郁量表二、Epworth 嗜睡量表和匹兹堡睡眠质量指数评分更高。与白班工人相比，轮班工人桥脑被盖部的灰质体积显著减少。桥脑被盖部的区域体积与匹兹堡睡眠质量指数的全球评分呈负相关。
与白班工人相比，我们观察到轮班工人的桥脑被盖部灰质体积减少，桥脑被盖部体积越小，睡眠质量越差。我们的初步发现可能与轮班工人的昼夜节律紊乱或接触明亮光线减少有关。
