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[柯萨奇B3病毒对新生仔猪胰岛细胞培养物的形态功能变化的影响]

[Morphofunctional changes in a culture of pancreatic islet cells from newborn piglets as affected by Coxsackie B3 viruses].

作者信息

Komissarenko V P, Turchin I S, Shirobokov V P, Zemlianskiĭ V V, Zhurba T B

出版信息

Probl Endokrinol (Mosk). 1987 May-Jun;33(3):50-4.

PMID:2821534
Abstract

The direct influence of Coxsackie virus B-3 and its selected variants Abent+ and Abent- on the function and structure of neonatal pig pancreatic islet cells in monolayer cultures was studied. The viruses under study possessed cytopathogenic activity and were capable of reproduction. The Abent- variant of Coxsackie virus B-3 possessed the most pronounced cytopathogenic activity. Direct correlation between virus reproduction and insulin concentration in a culture medium was established.

摘要

研究了柯萨奇病毒B-3及其选定变体Abent+和Abent-对单层培养的新生猪胰岛细胞功能和结构的直接影响。所研究的病毒具有细胞致病活性且能够繁殖。柯萨奇病毒B-3的Abent-变体具有最明显的细胞致病活性。建立了病毒繁殖与培养基中胰岛素浓度之间的直接相关性。

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