Valueva G V, Tron'ko N D, Slavnov V N, Iakovlev A A, Luchitskiĭ E V
Probl Endokrinol (Mosk). 1987 May-Jun;33(3):70-5.
Experiments on rats have shown that the dopamine agonist parlodel produces a noticeable inhibitory effect on function of the pituitary-adrenal system by a decrease in corticotropin secretion and direct influence on aldosterone synthesis and secretion. Changes in corticosterone level caused by parlodel are related to ACTH action and inhibition of activity of the microcirculatory bed of the adrenal fascicular zone. The dopamine agonist parlodel produces no effect on metabolism of the steroid hormones: corticosterone and testosterone in the rat hepatic tissue.
对大鼠的实验表明，多巴胺激动剂溴隐亭通过降低促肾上腺皮质激素分泌以及直接影响醛固酮的合成与分泌，对垂体-肾上腺系统的功能产生显著的抑制作用。溴隐亭引起的皮质酮水平变化与促肾上腺皮质激素的作用以及肾上腺束状带微循环床活性的抑制有关。多巴胺激动剂溴隐亭对大鼠肝组织中皮质酮和睾酮等类固醇激素的代谢没有影响。
