Valueva G V, Slavnov V N, Tron'ko N D, Markov V V, Luchitskiĭ E V
Farmakol Toksikol. 1986 Jul-Aug;49(4):54-7.
The effect of dopamine agonist parlodel (1 and 5 mg/kg) on the activity of the hypothalamic-pituitary-adrenal system, lactotropic and somatotropic pituitary functions was studied. The content of ACTH and corticosterone in the blood and tissue, aldosterone in the blood, prolactin, somatotropic hormone in the pituitary, catecholamines in the hypothalamus and cerebral cortex demonstrated the inhibitory effect of the drug on the functioning of the hypothalamic-pituitary-adrenal system, and pituitary, lactotropic and somatotropic functions. The mode of parlodel action consists probably in the decrease of turnover rather than in any changes of dopamine and catecholamine content in the hypothalamus and cerebral cortex. Parlodel failed to affect steroid metabolism in the body.
研究了多巴胺激动剂溴隐亭（1和5毫克/千克）对下丘脑-垂体-肾上腺系统活性、垂体催乳素和生长激素功能的影响。血液和组织中促肾上腺皮质激素（ACTH）和皮质酮的含量、血液中醛固酮的含量、垂体中的催乳素、生长激素、下丘脑和大脑皮层中的儿茶酚胺表明，该药物对下丘脑-垂体-肾上腺系统以及垂体、催乳素和生长激素功能具有抑制作用。溴隐亭的作用方式可能在于降低代谢率，而非下丘脑和大脑皮层中多巴胺和儿茶酚胺含量的任何变化。溴隐亭对体内类固醇代谢没有影响。
