Sawant M S, Leube R E
Institute of Molecular and Cellular Anatomy, RWTH Aachen University, Aachen, Germany.
Institute of Molecular and Cellular Anatomy, RWTH Aachen University, Aachen, Germany.
Int Rev Cell Mol Biol. 2017;330:171-225. doi: 10.1016/bs.ircmb.2016.09.005. Epub 2016 Dec 6.
Intermediate filaments are major phosphoproteins. The complex patterns of intermediate filament phosphorylation make up a poorly understood code reflecting cytoskeletal properties and cellular function through an intense crosstalk with multiple signaling pathways. This review focuses on the epithelial keratin intermediate filaments highlighting the tight-knit relationship of keratin phosphorylation and network organization during cell division and apoptosis, and the importance of keratin phosphorylation during epithelial stress responses. The occurrence of keratin phosphorylation in genetic skin diseases and acquired diseases of simple epithelial tissues in liver, pancreas, and colon will be discussed. Finally, we will review the role of keratin phosphorylation in cancer with an emphasis on migration.
中间丝是主要的磷蛋白。中间丝磷酸化的复杂模式构成了一个尚未被充分理解的密码，通过与多种信号通路的强烈相互作用反映细胞骨架特性和细胞功能。本综述聚焦于上皮角蛋白中间丝，强调在细胞分裂和凋亡过程中角蛋白磷酸化与网络组织的紧密关系，以及角蛋白磷酸化在上皮应激反应中的重要性。还将讨论角蛋白磷酸化在遗传性皮肤病以及肝脏、胰腺和结肠等简单上皮组织后天性疾病中的发生情况。最后，我们将综述角蛋白磷酸化在癌症中的作用，重点是迁移方面。
