分析人血清代谢组以鉴定糜烂性口腔扁平苔藓的潜在生物标志物。
Analysis of human serum metabolome for potential biomarkers identification of erosive oral lichen planus.
作者信息
Yang Xu-Yan, Zhang Shuai-Nan, Li Xu-Zhao, Wang Yu, Yin Xiao-Dong
机构信息
First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China.
Department of Pharmacy, Guiyang University of Chinese Medicine, Guiyang 550025, PR China.
出版信息
Clin Chim Acta. 2017 May;468:46-50. doi: 10.1016/j.cca.2017.02.010. Epub 2017 Feb 16.
BACKGROUND
Oral lichen planus (OLP) is a chronic auto-inflammatory mucositis and potentially oral premalignant lesion. Erosive OLP patients display the higher canceration rate as compared to the patients with non-erosive OLP. Identification of the potential biomarkers associated with erosive OLP may help to investigate the disease pathogenesis and to improve clinical treatment.
METHODS
Ultra-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-QTOF-MS) combined with pattern recognition approaches were integrated to acquire differentially expressed metabolites for the pathways analysis and elucidate mechanisms of disease.
RESULTS
Totally, 10 modulated metabolites were characterized as the potential biomarkers of erosive OLP, whose dysregulations could affect multiple metabolic pathways and pathological processes in the disease.
CONCLUSION
These findings indicated that the analysis of human serum metabolome might be conducive to the achievement of the objectives of this study.
背景
口腔扁平苔藓（OLP）是一种慢性自身炎症性黏膜炎，且可能是口腔潜在恶性病变。与非糜烂性OLP患者相比，糜烂性OLP患者的癌变率更高。识别与糜烂性OLP相关的潜在生物标志物可能有助于研究疾病发病机制并改善临床治疗。
方法
将超高效液相色谱-四极杆飞行时间质谱（UPLC-QTOF-MS）与模式识别方法相结合，以获取差异表达的代谢物用于通路分析并阐明疾病机制。
结果
总共鉴定出10种调节代谢物作为糜烂性OLP的潜在生物标志物，其失调可能影响该疾病的多个代谢途径和病理过程。
结论
这些发现表明，对人血清代谢组的分析可能有助于实现本研究的目标。
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