Ilves Liis, Ottas Aigar, Raam Liisi, Zilmer Mihkel, Traks Tanel, Jaks Viljar, Kingo Külli
Department of Dermatology and Venereology, University of Tartu, 50417 Tartu, Estonia.
Dermatology Clinic, Tartu University Hospital, 50417 Tartu, Estonia.
Metabolites. 2023 Jan 6;13(1):91. doi: 10.3390/metabo13010091.
Lichen planus is a chronic inflammatory mucocutaneous disease that belongs to the group of papulosquamous skin diseases among diseases like psoriasis, a widely studied disease in dermatology. The aim of the study was to identify the changes between the blood sera of lichen planus patients and healthy controls to widen the knowledge about the metabolomic aspect of lichen planus and gain a better understanding about the pathophysiology of the disease. We used high-throughput nuclear magnetic resonance (NMR) spectroscopy to measure the levels of blood serum metabolites, lipoproteins and lipoprotein particles. Dyslipidemia has relatively recently been shown to be one of the comorbidities of lichen planus, but the changes in the components of lipoproteins have not been described yet. We found statistically significant changes in the concentrations of 16 markers regarding lipoproteins, which included the components of intermediate-density lipoproteins, low-density lipoproteins and large low-density lipoproteins. We propose that the detected changes may increase the risk for specific comorbidities (e.g., dyslipidemia) and resulting cardiovascular diseases, as the turnover and hepatic uptake of the altered/modified lipoprotein particles are disturbed.
扁平苔藓是一种慢性炎症性黏膜皮肤疾病，属于丘疹鳞屑性皮肤病，与银屑病等疾病同属此类，银屑病是皮肤病学中广泛研究的一种疾病。本研究的目的是确定扁平苔藓患者与健康对照者血清之间的差异，以拓宽对扁平苔藓代谢组学方面的认识，并更好地理解该疾病的病理生理学。我们使用高通量核磁共振（NMR）光谱法来测量血清代谢物、脂蛋白和脂蛋白颗粒的水平。血脂异常最近被证明是扁平苔藓的合并症之一，但脂蛋白成分的变化尚未见描述。我们发现16种脂蛋白标志物的浓度有统计学显著变化，其中包括中密度脂蛋白、低密度脂蛋白和大低密度脂蛋白的成分。我们认为，检测到的这些变化可能会增加特定合并症（如血脂异常）及由此导致的心血管疾病的风险，因为改变/修饰后的脂蛋白颗粒的周转和肝脏摄取受到了干扰。
