Quinlan D C, Davidson A, Watne A L
Department of Biology, West Virginia University School of Medicine, Morgantown 26506.
Semin Surg Oncol. 1987;3(3):174-8. doi: 10.1002/ssu.2980030309.
Familial polyposis coli is a disease state that offers an opportunity to obtain colon tissue in a predictable manner in terms of identifying putative premalignant markers. Our results support the hypothesis that a sequential series of alterations occur in the dynamics of glycoprotein metabolism as normal colonic mucosa progresses to colon adenocarcinoma. Specifically, both nonmalignant polyps and colon adenocarcinoma tissue expressed diminished glycosylation of proteins, whereas an elevated level of activity for membrane-associated glycosyltransferases does not appear until colon cancer itself develops.
家族性腺瘤性息肉病是一种疾病状态，它为以可预测的方式获取结肠组织提供了机会，以便识别假定的癌前标志物。我们的结果支持这样一种假说，即随着正常结肠黏膜发展为结肠腺癌，糖蛋白代谢动态会发生一系列连续变化。具体而言，非恶性息肉和结肠腺癌组织中蛋白质糖基化均减少，而直到结肠癌本身发展时，膜相关糖基转移酶的活性水平才会升高。
