Slomski C A, Durham J P, Watne A L
J Surg Res. 1986 Apr;40(4):406-10. doi: 10.1016/0022-4804(86)90206-4.
Glycosyltransferase levels have been reported to be decreased in the tumor mucosa of adenocarcinoma of the colon. The purpose of this study was to determine if similar changes are present in the polyp mucosa of patients with Familial Polyposis Coli (FPC). The levels of eight glycosyltransferases were determined by measuring transfer of a radiolabeled sugar from a nucleotide sugar donor to a glycoprotein acceptor. The levels of four of the enzymes were significantly different in the mucosa of tumors and the polyp mucosa of patients with FPC as compared to the colonic mucosa of persons without known neoplastic disease. The changes were specific for these four enzymes and occurred to the same degree in tumor mucosa and the polyp mucosa. These changes in glycosyltransferase levels are a marker of the malignant transformation of the cell and since they occur in the histologically benign cells of FPC may serve as a key to understanding the neoplastic process.
据报道，结肠腺癌的肿瘤黏膜中糖基转移酶水平降低。本研究的目的是确定家族性结肠息肉病（FPC）患者的息肉黏膜中是否存在类似变化。通过测量放射性标记糖从核苷酸糖供体向糖蛋白受体的转移来测定八种糖基转移酶的水平。与无已知肿瘤疾病的人的结肠黏膜相比，FPC患者的肿瘤黏膜和息肉黏膜中四种酶的水平有显著差异。这些变化是这四种酶所特有的，并且在肿瘤黏膜和息肉黏膜中以相同程度发生。糖基转移酶水平的这些变化是细胞恶性转化的一个标志，并且由于它们发生在FPC的组织学良性细胞中，可能是理解肿瘤形成过程的关键。
