Pallav Kumar, Riche Daniel, May Warren L, Sanchez Patrick, Gupta Nitin K
Kumar Pallav, Patrick Sanchez, Nitin K Gupta, Division of Digestive Diseases, University of Mississippi Medical Center, Jackson, MS 39216, United States.
World J Gastroenterol. 2017 Jan 28;23(4):638-645. doi: 10.3748/wjg.v23.i4.638.
To identify the predictors of vitamin D deficiency in patients with and without inflammatory bowel disease (IBD).
Patients with ulcerative colitis (UC) or Crohn's disease (CD) related diagnostic codes who received medical care at University of Mississippi Medical Center between July 2012 and 2015 were identified. After thorough chart review, we identified patients with biopsy proven IBD who had also been tested for serum 25-hydroxyvitamin D [25(OH)D] concentration. We compared these patients to a previously studied cohort of healthy controls who also had vitamin D concentration checked. Logistic regression analysis was performed to determine the association between vitamin d deficiency and UC, CD, race, age, gender and body mass index (BMI).
We identified 237 patients with confirmed IBD. Of these, only 211 had a serum 25(OH)D concentrations available in the medical record. The group of healthy controls consisted of 98 individuals with available serum 25(OH)D concentration. 43% of IBD patients were African American (AA). Patients with CD were more likely to have vitamin D concentration checked. Bivariate analysis showed that AA (51% 21%, = 0.00001), subjects with BMI >30 kg/m (39% 23% = 0.01) and CD (40% 26%, = 0.04) were more likely to be vitamin D deficient than vitamin D sufficient. Those with Age > 65 were more likely to be vitamin D sufficient (46% 15%, = 0.04). Multiple regression showed that only BMI > 30 kg/m and AA race are associated with vitamin D deficiency.
BMI > 30 kg/m and AA race are predictive of vitamin D deficiency. Gender, age and diagnosis of IBD are not predictive of vitamin D deficiency.
确定患有和未患有炎症性肠病（IBD）的患者维生素D缺乏的预测因素。
识别出2012年7月至2015年期间在密西西比大学医学中心接受治疗且具有溃疡性结肠炎（UC）或克罗恩病（CD）相关诊断编码的患者。在全面查阅病历后，我们确定了经活检证实患有IBD且同时检测了血清25-羟维生素D [25(OH)D]浓度的患者。我们将这些患者与之前研究过的一组也检测了维生素D浓度的健康对照者进行比较。进行逻辑回归分析以确定维生素D缺乏与UC、CD、种族、年龄、性别和体重指数（BMI）之间的关联。
我们识别出237例确诊的IBD患者。其中，病历中仅有211例有血清25(OH)D浓度数据。健康对照组由98名有可用血清25(OH)D浓度数据的个体组成。43%的IBD患者是非裔美国人（AA）。患有CD的患者更有可能检测维生素D浓度。双变量分析显示，与维生素D充足的患者相比，AA（51%对21%，P = 0.00001）、BMI>30 kg/m的受试者（39%对23%，P = 0.01）和CD患者（40%对26%，P = 0.04）更有可能维生素D缺乏。年龄大于6岁的患者更有可能维生素D充足（46%对15%，P = = 0.04）。多元回归显示，只有BMI>30 kg/m和AA种族与维生素D缺乏相关。
BMI>30 kg/m和AA种族可预测维生素D缺乏情况。性别、年龄和IBD诊断不能预测维生素D缺乏情况。
