Dell'Anna Giuseppe, Fanizzi Fabrizio, Zilli Alessandra, Furfaro Federica, Solitano Virginia, Parigi Tommaso Lorenzo, Ciliberto Ambra, Fanizza Jacopo, Mandarino Francesco Vito, Fuccio Lorenzo, Facciorusso Antonio, Donatelli Gianfranco, Allocca Mariangela, Massironi Sara, Annese Vito, Peyrin-Biroulet Laurent, Danese Silvio, D'Amico Ferdinando
Gastroenterology and Gastrointestinal Endoscopy Division, IRCCS San Raffaele Hospital, Via Olgettina 60, 20132 Milan, Italy.
Gastroenterology and Gastrointestinal Endoscopy Division, IRCCS Policlinico San Donato, Piazza Edmondo Malan 2, 20097 San Donato Milanese, Italy.
Nutrients. 2025 Jun 29;17(13):2167. doi: 10.3390/nu17132167.
Vitamin D plays a crucial role in immune modulation, gut barrier integrity, and inflammation regulation, making it highly relevant in inflammatory bowel disease (IBD). IBD patients often exhibit vitamin D deficiency, which has been linked to increased disease activity, impaired mucosal healing, and a higher risk of complications, including infections and osteoporosis.
This review examines the biological functions of vitamin D in maintaining intestinal homeostasis, particularly in the context of IBD. It discusses the prevalence and consequences of vitamin D deficiency in IBD, including its potential to exacerbate disease progression, impair treatment efficacy, and negatively impact long-term health outcomes. Furthermore, therapeutic strategies to address vitamin D deficiency are explored, including supplementation approaches, dosing strategies, and precision nutrition interventions that aim to personalize vitamin D management based on individual patient needs and disease characteristics.
By synthesizing the latest evidence, this review highlights the critical role of vitamin D in IBD management, underlining how optimal vitamin D levels may not only improve disease control but also enhance patient quality of life and reduce the risk of long-term complications associated with the disease.
Understanding the importance of vitamin D in IBD could help refine treatment strategies and promote better health outcomes for affected individuals.
维生素D在免疫调节、肠道屏障完整性和炎症调节中起着关键作用，使其在炎症性肠病（IBD）中具有高度相关性。IBD患者常表现出维生素D缺乏，这与疾病活动增加、黏膜愈合受损以及包括感染和骨质疏松症在内的并发症风险较高有关。
本综述探讨了维生素D在维持肠道稳态中的生物学功能，特别是在IBD背景下。它讨论了IBD中维生素D缺乏的患病率和后果，包括其加剧疾病进展、损害治疗效果以及对长期健康结果产生负面影响的可能性。此外，还探讨了应对维生素D缺乏的治疗策略，包括补充方法、给药策略以及旨在根据个体患者需求和疾病特征个性化管理维生素D的精准营养干预措施。
通过综合最新证据，本综述强调了维生素D在IBD管理中的关键作用，强调了最佳维生素D水平不仅可以改善疾病控制，还可以提高患者生活质量并降低与该疾病相关的长期并发症风险。
了解维生素D在IBD中的重要性有助于优化治疗策略，并为受影响个体带来更好的健康结果。
