Türkölmez Şeyda, Aksoy Sabire Yılmaz, Özdemir Elif, Kandemir Zuhal, Yıldırım Nilüfer, Özsavran Atiye Yılmaz, Çetindağ Mehmet Faik, Köse Kenan
Department of Nuclear Medicine, Ankara Ataturk Training and Research Hospital, Yıldırım Beyazıt University, Ankara, Turkey.
Department of Nuclear Medicine, Ankara Ataturk Training and Research Hospital, Ankara, Turkey.
World J Nucl Med. 2017 Jan-Mar;16(1):33-38. doi: 10.4103/1450-1147.181151.
The aim of this study was to investigate the prognostic significance of standardized uptake value (SUV) on 18 fluorine-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) in patients with nasopharyngeal carcinoma (NPC). Thirty-four patients who have histologically proven NPC and underwent F-FDG PET/CT were included in this study. After F-FDG PET/CT, all the patients received radiation therapy and 32 of them received concomitant weekly chemotherapy. The maximum SUV (SUV) at the primary tumor and the SUVof the highest neck nodes were determined. The SUV-T ranged from 5.00 to 30.80 (mean: 15.37 ± 6.10) and there was no difference between SUV-T values for early and late stages ( = 0.99). The SUV-N ranged from 3.10 to 23.80 (mean: 13.23 ± 5.76). There was no correlation between SUV-T and SUV-N ( = 0.111, = 0.532). There was no difference between the SUV-T and the positivity of neck lymph nodes ( = 0.169). The ability of SUV-N to predict stage was obtained by a receiver operating characteristic (ROC) analysis. The area under the curve is 0.856 and the best cut-off value is 7.88. There was a good correlation between SUV-N and stage. While the mean SUV-T for the alive patients was slightly lower than that for the dead (14.65 ± 5.58 vs. 20.30 ± 7.92, = 0.061), the difference between the groups was not statistically significant. Furthermore, there was no statistically significant difference for SUV-N between these two groups (P: 0.494). Cox-regression analysis showed that an increase in SUV-T and SUV-N was associated with death risk (relative risk [RR]: 1.13, = 0.078 and RR: 1.052, = 0.456, respectively). SUV-T and SUV-N were independent prognostic factors for survival in NPC patients. This will help the clinicians in choosing suitable candidates for more aggressive treatment modalities.
本研究旨在探讨18氟-氟脱氧葡萄糖（F-FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）中标准化摄取值（SUV）对鼻咽癌（NPC）患者的预后意义。本研究纳入了34例经组织学证实为NPC且接受F-FDG PET/CT检查的患者。F-FDG PET/CT检查后，所有患者均接受放射治疗，其中32例患者接受每周一次的同步化疗。测定原发肿瘤的最大SUV（SUV）和颈部最高淋巴结的SUV。SUV-T范围为5.00至30.80（平均：15.37±6.10），早期和晚期的SUV-T值之间无差异（P = 0.99）。SUV-N范围为3.10至23.80（平均：13.23±5.76）。SUV-T与SUV-N之间无相关性（P = 0.111，r = 0.532）。SUV-T与颈部淋巴结阳性之间无差异（P = 0.169）。通过受试者工作特征（ROC）分析获得SUV-N预测分期的能力。曲线下面积为0.856，最佳截断值为7.88。SUV-N与分期之间存在良好的相关性。虽然存活患者的平均SUV-T略低于死亡患者（14.65±5.58对20.30±7.92，P = 0.061），但两组之间的差异无统计学意义。此外，两组之间的SUV-N也无统计学显著差异（P：0.494）。Cox回归分析显示，SUV-T和SUV-N的增加与死亡风险相关（相对风险[RR]：1.13，P = 0.078和RR：1.052，P = 0.456，分别）。SUV-T和SUV-N是NPC患者生存独立的预后因素。这将有助于临床医生选择更积极治疗方式的合适候选者。
