吸入麻醉气体对急性脑损伤的抗氧化作用
Anti-oxidative aspect of inhaled anesthetic gases against acute brain injury.
作者信息
Yang Tuo, Sun Yang, Zhang Feng
机构信息
Department of Neurology, Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Neurology, Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh, Pittsburgh, PA, USA; Geriatric Research, Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA, USA; Key Lab of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong Province, China.
出版信息
Med Gas Res. 2016 Dec 30;6(4):223-226. doi: 10.4103/2045-9912.196905. eCollection 2016 Oct-Dec.
Abstract
Acute brain injury is a critical and emergent condition in clinical settings, which needs to be addressed urgently. Commonly acute brain injuries include traumatic brain injury, ischemic and hemorrhagic strokes. Oxidative stress is a key contributor to the subsequent injuries and impedes the reparative process after acute brain injury; therefore, facilitating an anti-oxidative approach is important in the care of those diseases. Readiness to deliver and permeability to blood brain barrier are essential for the use of this purpose. Inhaled anesthetic gases are a group of such agents. In this article, we discuss the anti-oxidative roles of anesthetic gases against acute brain injury.
摘要
急性脑损伤是临床中的一种危急重症，需要紧急处理。常见的急性脑损伤包括创伤性脑损伤、缺血性和出血性中风。氧化应激是导致后续损伤的关键因素，并阻碍急性脑损伤后的修复过程；因此，采用抗氧化方法对这些疾病的治疗很重要。为此目的使用时，药物的可递送性和血脑屏障通透性至关重要。吸入麻醉气体就是这类药物。在本文中，我们讨论麻醉气体对急性脑损伤的抗氧化作用。
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