Institute of Neuroregeneration & Neurorehabilitation, Department of Pathophysiology, School of Basic Medicine, Qingdao University, Qingdao, 266071, Shandong Province, China.
Institute of Neuroregeneration & Neurorehabilitation, Department of Pathophysiology, School of Basic Medicine, Qingdao University, Qingdao, 266071, Shandong Province, China.
Chin J Traumatol. 2023 Jan;26(1):20-26. doi: 10.1016/j.cjtee.2022.06.008. Epub 2022 Jul 3.
Panax notoginseng is an ancient Chinese medicinal plant that has great clinical value in regulating cardiovascular disease in China. As a single component of panax notoginosides, notoginsenoside R1 (NGR1) belongs to the panaxatriol group. Many reports have demonstrated that NGR1 exerts multiple pharmacological effects in ischemic stroke, myocardial infarction, acute renal injury, and intestinal injury. Here, we outline the available reports on the pharmacological effects of NGR1 in ischemia-reperfusion (I/R) injury. We also discuss the chemistry, composition and molecular mechanism underlying the anti-I/R injury effects of NGR1. NGR1 had significant effects on reducing cerebral infarct size and neurological deficits in cerebral I/R injury, ameliorating the impaired mitochondrial morphology in myocardial I/R injury, decreasing kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin in renal I/R injury and attenuating jejunal mucosal epithelium injury in intestinal I/R injury. The various organ anti-I/R injury effects of NGR1 are mainly through the suppression of oxidative stress, apoptosis, inflammation, endoplasmic reticulum stress and promotion of angiogenesis and neurogenesis. These findings provide a reference basis for future research of NGR1 on I/R injury.
三七是一种中国传统药用植物，在中国调节心血管疾病方面具有巨大的临床价值。作为三七总皂苷的单一成分，人参皂苷 R1（NGR1）属于达玛烷二醇组。许多报道表明，NGR1 在缺血性脑卒中、心肌梗死、急性肾损伤和肠损伤中具有多种药理作用。在这里，我们概述了 NGR1 在缺血再灌注（I/R）损伤中的药理学作用的现有报道。我们还讨论了 NGR1 抗 I/R 损伤作用的化学、组成和分子机制。NGR1 对脑 I/R 损伤中减少脑梗死面积和神经功能缺损、改善心肌 I/R 损伤中受损的线粒体形态、减少肾 I/R 损伤中的肾损伤分子-1 和中性粒细胞明胶酶相关脂质运载蛋白以及减轻肠 I/R 损伤中的空肠黏膜上皮损伤有显著作用。NGR1 的各种器官抗 I/R 损伤作用主要是通过抑制氧化应激、细胞凋亡、炎症、内质网应激以及促进血管生成和神经发生。这些发现为 NGR1 对 I/R 损伤的未来研究提供了参考依据。
