抗炎信号传导：医用气体在缺血性中风神经保护中的汇聚点。
Anti-inflammatory signaling: the point of convergence for medical gases in neuroprotection against ischemic stroke.
作者信息
Li Pei-Ying, Wang Xin, Stetler R Anne, Chen Jun, Yu Wei-Feng
机构信息
Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
出版信息
Med Gas Res. 2016 Dec 30;6(4):227-231. doi: 10.4103/2045-9912.196906. eCollection 2016 Oct-Dec.
Abstract
Recent studies suggest that a variety of medical gases confer neuroprotective effects against cerebral ischemia, extending function beyond their regular clinical applications. The mechanisms underlying ischemic neuroprotection afforded by medical gases have been intensively studied over the past two decades. A number of signaling pathways have been proposed, among which anti-inflammatory signaling has been proven to be critical. Pursuit of the role for anti-inflammatory signaling may shed new light on the translational application of medical gas-afforded neuroprotection.
摘要
最近的研究表明，多种医用气体对脑缺血具有神经保护作用，其功能扩展到了常规临床应用之外。在过去二十年中，人们对医用气体提供缺血性神经保护的潜在机制进行了深入研究。已经提出了许多信号通路，其中抗炎信号已被证明至关重要。对抗炎信号作用的探索可能会为医用气体神经保护的转化应用带来新的启示。
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