光遗传学介导的运动皮层刺激在慢性神经性疼痛治疗中的应用。
Application of optogenetics-mediated motor cortex stimulation in the treatment of chronic neuropathic pain.
作者信息
Liu Sufang, Tao Feng
机构信息
Department of Biomedical Sciences, Texas A&M University Baylor College of Dentistry, Dallas, Texas, USA; Department of Physiology, Zhengzhou University School of Medicine, Zhengzhou, Henan, China.
Department of Biomedical Sciences, Texas A&M University Baylor College of Dentistry, Dallas, Texas, USA; Center for Craniofacial Research and Diagnosis, Texas A&M University Baylor College of Dentistry, Dallas, Texas, USA.
出版信息
J Transl Sci. 2016;2(5):286-288. doi: 10.15761/JTS.1000153. Epub 2016 Jul 11.
Abstract
Motor cortex stimulation provides an alternate approach for intractable pain treatment. Optogenetic manipulation can produce gain- or loss-of-function in specific type of cells following light application. This state-of-the-art technology may be used in motor cortex stimulation to produce circuit-specific neuromodulation and regulate neuronal activities in motor cortex, thereby treating pain in the clinic. Here, we discuss the principle of optogenetics-mediated motor cortex stimulation and discuss its potential application in the treatment of chronic neuropathic pain.
摘要
运动皮层刺激为顽固性疼痛治疗提供了一种替代方法。光遗传学操作可在光照后在特定类型的细胞中产生功能增强或功能丧失。这项先进技术可用于运动皮层刺激，以产生特定回路的神经调节并调节运动皮层中的神经元活动，从而在临床上治疗疼痛。在此，我们讨论光遗传学介导的运动皮层刺激的原理，并探讨其在慢性神经性疼痛治疗中的潜在应用。
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