Bahuguna Rachana, Jain Atul, Khan Suleman Abbas, Arvind M S
Department of Pedodontics, RKDF Dental College and Research Centre, Bhopal, Madhya Pradesh, India.
Department of Conservative Dentistry and Endodontics, RKDF Dental College and Research Centre, Bhopal, Madhya Pradesh, India.
J Int Soc Prev Community Dent. 2016 Dec;6(Suppl 3):S175-S181. doi: 10.4103/2231-0762.197183.
Through a comprehensive literature review, this article provides an overview of the potential role of odanacatib (ODN) in reducing bone loss due to endodontic disease.
A literature review was performed in PubMed Central, MEDLINE, Cochrane Library, and EBSCO databases. The articles identified included those published between 2002 and 2016. Based on the predetermined inclusion and exclusion criteria, out of 237 articles found, 50 were selected for this review.
Cathepsin K (CstK), which is indispensible to the immune system, also plays an important role in osteoclastic bone resorption. ODN, which is an orally active, selective, and effective inhibitor of CstK, decreases bone resorption by selectively inhibiting proteolysis of matrix proteins by CstK, without affecting other osteoclastic activity or osteoblast viability.
The goal of endodontic treatment is to achieve a clinically asymptomatic state along with formation of reparative bone. This process could take 6 months or longer, hence, an earlier reversal of the resorption process could lead to faster healing and resolution of the periapical lesion. Use of ODN can be of help in achieving this goal.
通过全面的文献综述，本文概述了odanacatib（ODN）在减少牙髓疾病所致骨质流失方面的潜在作用。
在PubMed Central、MEDLINE、Cochrane图书馆和EBSCO数据库中进行了文献综述。所识别的文章包括2002年至2016年期间发表的文章。根据预先确定的纳入和排除标准，在找到的237篇文章中，有50篇被选入本综述。
组织蛋白酶K（CstK）对免疫系统不可或缺，在破骨细胞骨吸收中也起重要作用。ODN是一种口服活性、选择性且有效的CstK抑制剂，通过选择性抑制CstK对基质蛋白的蛋白水解作用来减少骨吸收，而不影响其他破骨细胞活性或成骨细胞活力。
牙髓治疗的目标是实现临床无症状状态并形成修复性骨。这个过程可能需要6个月或更长时间，因此，更早地逆转吸收过程可导致根尖周病变更快愈合和消退。使用ODN有助于实现这一目标。
