巴贝斯虫病相关免疫性血小板减少症
Babesiosis-associated immune thrombocytopenia.
作者信息
Narurkar Roshni, Mamorska-Dyga Aleksandra, Agarwal Anup, Nelson John C, Liu Delong
机构信息
Department of Medicine, New York Medical College and Westchester Medical Center, Valhalla, NY 10595, USA.
出版信息
Stem Cell Investig. 2017 Jan 17;4:1. doi: 10.21037/sci.2017.01.02. eCollection 2017.
Abstract
Thrombocytopenia is a common feature of babesiosis. The mechanism for thrombocytopenia in babesiosis remains elusive. We report a case of babesiosis with severe new onset immune thrombocytopenia (ITP). In addition to antibiotics treatment for babesiosis, ITP therapy was administered. ITP in the present case was most likely triggered by the babesia infection. The severity of ITP in this case was not proportional to the severity of parasitemia. The neoantigen triggering the autoimmune response in babesiosis requires further characterization.
摘要
血小板减少是巴贝斯虫病的常见特征。巴贝斯虫病中血小板减少的机制仍不清楚。我们报告一例新发严重免疫性血小板减少症（ITP）合并巴贝斯虫病的病例。除了针对巴贝斯虫病的抗生素治疗外，还给予了ITP治疗。本例ITP很可能是由巴贝斯虫感染引发的。该病例中ITP的严重程度与寄生虫血症的严重程度不成比例。巴贝斯虫病中引发自身免疫反应的新抗原需要进一步鉴定。
相似文献
1
Babesiosis-associated immune thrombocytopenia.巴贝斯虫病相关免疫性血小板减少症
Stem Cell Investig. 2017 Jan 17;4:1. doi: 10.21037/sci.2017.01.02. eCollection 2017.
2
Congenital Babesiosis From Maternal Exposure: A Case Report.母体暴露导致的先天性巴贝斯虫病：一例报告
J Emerg Med. 2019 Apr;56(4):e39-e41. doi: 10.1016/j.jemermed.2018.12.044. Epub 2019 Jan 29.
3
Serendipitous Finding of Asymptomatic Babesiosis in a Patient With Symptomatic Thrombocytopenia.在一名有症状性血小板减少症患者中意外发现无症状巴贝斯虫病。
J Hematol. 2019 Dec;8(4):168-170. doi: 10.14740/jh570. Epub 2019 Dec 25.
4
Age-Related Differential Stimulation of Immune Response by and During Acute Phase of Infection Affects Disease Severity.年龄相关的免疫反应差异刺激 通过 和 在感染急性期影响疾病严重程度。
Front Immunol. 2018 Dec 7;9:2891. doi: 10.3389/fimmu.2018.02891. eCollection 2018.
5
Profound autoimmune hemolysis and Evans syndrome in two asplenic patients with babesiosis.两名患有巴贝斯虫病的无脾患者发生严重自身免疫性溶血和伊文氏综合征。
Transfusion. 2015 Mar;55(3):661-5. doi: 10.1111/trf.12901. Epub 2014 Oct 29.
6
Therapeutic apheresis for babesiosis.巴贝斯虫病的治疗性血液成分单采术
J Clin Apher. 1998;13(1):32-6. doi: 10.1002/(sici)1098-1101(1998)13:1<32::aid-jca7>3.0.co;2-a.
7
8
Autoimmune hemolytic anemia associated with babesiosis.与巴贝斯虫病相关的自身免疫性溶血性贫血。
Biomark Res. 2017 Apr 8;5:14. doi: 10.1186/s40364-017-0095-6. eCollection 2017.
9
Elimination of Is Dependent on Intraerythrocytic Killing and CD4 T Cells.清除依赖于红细胞内杀伤作用和CD4 T细胞。
J Immunol. 2017 Jul 15;199(2):633-642. doi: 10.4049/jimmunol.1601193. Epub 2017 Jun 12.
10
Prevalence of canine Babesia and Ehrlichia co-infection and the predictive value of haematology.犬巴贝斯虫和埃立克体混合感染的患病率及血液学的预测价值
Onderstepoort J Vet Res. 2018 Oct 9;85(1):e1-e5. doi: 10.4102/ojvr.v85i1.1626.
引用本文的文献
1
Severe Thrombocytopenia Secondary to Babesiosis: A Case Report.巴贝斯虫病继发严重血小板减少症：一例报告
Case Rep Hematol. 2025 Jul 1;2025:9918329. doi: 10.1155/crh/9918329. eCollection 2025.
2
Case Report: Concurrent Babesiosis and GCA/PMR.病例报告：同时发生的巴贝斯虫病与巨细胞动脉炎/风湿性多肌痛
Immun Inflamm Dis. 2025 Mar;13(3):e70182. doi: 10.1002/iid3.70182.
3
Severe Cystic Echinococcosis-Associated Immune Thrombocytopenic Purpura: A Case Report.重度囊性棘球蚴病相关免疫性血小板减少性紫癜：一例报告
J Hematol. 2021 Apr;10(2):71-75. doi: 10.14740/jh789. Epub 2021 Apr 27.
4
Serendipitous Finding of Asymptomatic Babesiosis in a Patient With Symptomatic Thrombocytopenia.在一名有症状性血小板减少症患者中意外发现无症状巴贝斯虫病。
J Hematol. 2019 Dec;8(4):168-170. doi: 10.14740/jh570. Epub 2019 Dec 25.
5
Autoimmune hemolytic anemia associated with babesiosis.与巴贝斯虫病相关的自身免疫性溶血性贫血。
Biomark Res. 2017 Apr 8;5:14. doi: 10.1186/s40364-017-0095-6. eCollection 2017.
本文引用的文献
1
Haematologic complications from human babesiosis: a case report.
New Microbes New Infect. 2015 Oct 23;8:148-9. doi: 10.1016/j.nmni.2015.10.008. eCollection 2015 Nov.
2
Blood film findings in severe babesiosis.重症巴贝斯虫病的血涂片检查结果
Br J Haematol. 2016 Mar;172(6):839. doi: 10.1111/bjh.13845. Epub 2015 Nov 16.
3
Desialylation is associated with apoptosis and phagocytosis of platelets in patients with prolonged isolated thrombocytopenia after allo-HSCT.在异基因造血干细胞移植后长期孤立性血小板减少症患者中，去唾液酸化与血小板的凋亡和吞噬作用相关。
J Hematol Oncol. 2015 Oct 23;8:116. doi: 10.1186/s13045-015-0216-3.
4
Biomarkers for immune thrombocytopenia.免疫性血小板减少症的生物标志物。
Biomark Res. 2015 Jul 16;3:19. doi: 10.1186/s40364-015-0045-0. eCollection 2015.
5
T cell immune abnormalities in immune thrombocytopenia.免疫性血小板减少症中的T细胞免疫异常
J Hematol Oncol. 2014 Oct 2;7:72. doi: 10.1186/s13045-014-0072-6.
6
The serum levels of the cytokines involved in the Th17 and Th1 cell commitment are increased in individuals with borderline thrombocytopenia.在血小板边缘减少症患者中，参与 Th17 和 Th1 细胞定型的细胞因子的血清水平升高。
J Hematol Oncol. 2013 Apr 12;6:28. doi: 10.1186/1756-8722-6-28.
7
Human babesiosis.人类巴贝斯虫病
N Engl J Med. 2012 Jun 21;366(25):2397-407. doi: 10.1056/NEJMra1202018.
8
Update on babesiosis.巴贝斯虫病的最新情况。
Interdiscip Perspect Infect Dis. 2009;2009:984568. doi: 10.1155/2009/984568. Epub 2009 Aug 27.
9
Tick-borne diseases in transfusion medicine.
Transfus Med. 2002 Apr;12(2):85-106. doi: 10.1046/j.1365-3148.2002.00358.x.
10
Clinical picture: human babesiosis.临床表现：人类巴贝斯虫病。
Lancet. 2001 Feb 3;357(9253):341. doi: 10.1016/s0140-6736(00)03640-0.
Zotero 插件