There will be blood: hematopoiesis control by mediator subunit MED12.
作者信息
Boyer Thomas G
机构信息
Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
出版信息
Stem Cell Investig. 2017 Jan 21;4:4. doi: 10.21037/sci.2016.12.02. eCollection 2017.
Abstract
摘要
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There will be blood: hematopoiesis control by mediator subunit MED12.血流将至：中介亚基MED12对造血的调控
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Prevalence and clinical significance of mediator complex subunit 12 mutations in 362 Han Chinese samples with uterine leiomyoma.362例汉族子宫平滑肌瘤样本中介体复合物亚基12突变的患病率及临床意义
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Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms.前列腺癌和子宫平滑肌瘤中的体细胞MED12突变通过不同机制促进肿瘤发生。
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A precisely positioned MED12 activation helix stimulates CDK8 kinase activity.精确定位的 MED12 激活螺旋刺激 CDK8 激酶活性。
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A Computational Protein Phenotype Prediction Approach to Analyze the Deleterious Mutations of Human MED12 Gene.一种用于分析人类MED12基因有害突变的计算蛋白质表型预测方法。
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MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.MED12 基因是中介复合物亚基 12 基因，在子宫平滑肌瘤中高频突变。
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MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs.CARM1介导的MED12甲基化使人类乳腺癌细胞对化疗药物敏感。
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本文引用的文献
1
MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis.MED12独立于中介体激酶活性调节造血干细胞特异性增强子以控制造血作用。
Cell Stem Cell. 2016 Dec 1;19(6):784-799. doi: 10.1016/j.stem.2016.08.004. Epub 2016 Aug 25.
2
Mediator subunit Med12 contributes to the maintenance of neural stem cell identity.中介体亚基Med12有助于维持神经干细胞的特性。
BMC Dev Biol. 2016 May 17;16(1):17. doi: 10.1186/s12861-016-0114-0.
3
Mediator kinase inhibition further activates super-enhancer-associated genes in AML.中介激酶抑制进一步激活急性髓系白血病中与超级增强子相关的基因。
Nature. 2015 Oct 8;526(7572):273-276. doi: 10.1038/nature14904. Epub 2015 Sep 28.
4
Mediator kinase module and human tumorigenesis.介质激酶模块与人类肿瘤发生
Crit Rev Biochem Mol Biol. 2015;50(5):393-426. doi: 10.3109/10409238.2015.1064854. Epub 2015 Jul 16.
5
Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia.体细胞MED12突变与慢性淋巴细胞白血病的不良预后标志物相关。
Oncotarget. 2015 Jan 30;6(3):1884-8. doi: 10.18632/oncotarget.2753.
6
Cyclin C is a haploinsufficient tumour suppressor.细胞周期蛋白C是一种单倍剂量不足的肿瘤抑制因子。
Nat Cell Biol. 2014 Nov;16(11):1080-91. doi: 10.1038/ncb3046. Epub 2014 Oct 26.
7
Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity.与子宫平滑肌瘤相关的MED12突变会破坏与中介体相关的CDK活性。
Cell Rep. 2014 May 8;7(3):654-60. doi: 10.1016/j.celrep.2014.03.047. Epub 2014 Apr 18.
8
Super-enhancers in the control of cell identity and disease.超级增强子在细胞身份和疾病中的调控作用。
Cell. 2013 Nov 7;155(4):934-47. doi: 10.1016/j.cell.2013.09.053. Epub 2013 Oct 10.
9
Mediator subunit 12 is required for neutrophil development in zebrafish.中介亚基 12 是斑马鱼中性粒细胞发育所必需的。
PLoS One. 2011;6(8):e23845. doi: 10.1371/journal.pone.0023845. Epub 2011 Aug 25.
10
Mediator and human disease.中介体和人类疾病。
Semin Cell Dev Biol. 2011 Sep;22(7):776-87. doi: 10.1016/j.semcdb.2011.07.024. Epub 2011 Aug 4.
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