Erdur Laurence, Weber Cora, Zimmermann-Viehoff Frank, Rose Matthias, Deter Hans-Christian
Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Germany.
Department of Psychiatry and Psychotherapy, Ernst von Bergmann Klinikum, Potsdam, Germany.
Eur Eat Disord Rev. 2017 Mar;25(2):114-122. doi: 10.1002/erv.2502.
There is an evolving debate about pathological affective responses in patients with anorexia nervosa (AN). We examined startle responses in different stages of AN.
We applied a startle reflex paradigm with standardized visual stimuli (International Affective Pictures System; food and body pictures) in 64 female participants (17 acute AN, 16 chronically ill AN, 15 long-term recovered AN, 16 healthy controls). We measured subjective ratings of valence and anxiety, and electromyographic startle responses.
Participants with acute and chronic AN displayed the same subjective valence ratings to affective stimuli but showed less startle reactivity to affective pictures (F(6, 116) = 2.75, p = .02) compared with healthy control. Food pictures were rated as more unpleasant and higher anxiety provoking by currently ill AN (F(3, 59) = 3.32, p=.03).
We observed diverging subjective and psychophysiological reactions in different stages of AN. Psychophysiological methods can help to attain a more comprehensive understanding of biological alterations in the long-term course of AN. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.
关于神经性厌食症（AN）患者的病理性情感反应的争论不断发展。我们研究了AN不同阶段的惊跳反应。
我们对64名女性参与者（17名急性AN患者、16名慢性病理性AN患者、15名长期康复的AN患者、16名健康对照者）应用了带有标准化视觉刺激（国际情感图片系统；食物和身体图片）的惊跳反射范式。我们测量了效价和焦虑的主观评分以及肌电图惊跳反应。
急性和慢性AN患者对情感刺激的主观效价评分相同，但与健康对照相比，对情感图片的惊跳反应性较低（F(6, 116) = 2.75，p = .02）。当前患病的AN患者将食物图片评为更不愉快且引发更高焦虑（F(3, 59) = 3.32，p = .03）。
我们观察到AN不同阶段的主观和心理生理反应存在差异。心理生理学方法有助于更全面地理解AN长期病程中的生物学改变。版权所有© 2017约翰·威利父子有限公司和饮食失调协会。
