西罗莫司成功用于治疗一名患有心脏横纹肌瘤儿童的难治性房性异位性心动过速。
Successful use of sirolimus for refractory atrial ectopic tachycardia in a child with cardiac rhabdomyoma.
作者信息
Ninic Sanja, Kalaba Marija, Jovicic Bosiljka, Vukomanovic Vladislav, Prijic Sergej, Vucetic Biljana, Kravljanac Ruzica, Vujic Ana, Kosutic Jovan
机构信息
Cardiology and Neurology Departments, Mother and Child Health Institute of Serbia, Belgrade, Serbia.
School of Medicine, University of Belgrade, Belgrade, Serbia.
出版信息
Ann Noninvasive Electrocardiol. 2017 Jul;22(4). doi: 10.1111/anec.12435. Epub 2017 Feb 19.
Abstract
Cardiac rhabdomyomas are common in tuberous sclerosis. We report a child who developed rhabdomyoma related arrhythmia refractory to antiarrhythmic drug therapy. Reversion of the atrial ectopic tachycardia was achieved with mammalian target of rapamycin pathway (mTOR) inhibitor sirolimus. As per our knowledge, this is the first time that sirolimus has been successfully used in this setting.
摘要
心脏横纹肌瘤在结节性硬化症中很常见。我们报告了一名儿童，其发生了与横纹肌瘤相关的心律失常，对抗心律失常药物治疗无效。使用雷帕霉素靶蛋白通路（mTOR）抑制剂西罗莫司实现了房性异位性心动过速的逆转。据我们所知，这是西罗莫司首次在这种情况下成功应用。
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