Weiss L M, Michie S A, Medeiros L J, Strickler J G, Garcia C F, Warnke R A
Department of Pathology, Stanford University Medical Center, California 94305.
Am J Clin Pathol. 1987 Oct;88(4):483-5. doi: 10.1093/ajcp/88.4.483.
Anti-Tac is a monoclonal antibody that appears to recognize the interleukin-2 receptor. With the use of a frozen-section immunoperoxidase technic, a large series of non-Hodgkin's lymphomas were investigated for the presence of Tac-antigen on neoplastic cells. Approximately one-fourth of cases expressed the Tac antigen, including 27% of B-lineage lymphomas, 6% of the T-lineage lymphomas, and three of four cases of Ki-1-expressing lymphoma. The B-lineage lymphomas with the highest incidence of Tac antigen expression were the large cell lymphomas, both diffuse and follicular, where about one-half of cases expressed the Tac antigen. All major categories of lymphoma expressed Tac except plasma-cytoma/myeloma, small noncleaved cell (Burkitt's and non-Burkitt's), and lymphoblastic malignancies.
抗Tac是一种单克隆抗体，似乎能识别白细胞介素-2受体。运用冷冻切片免疫过氧化物酶技术，对大量非霍奇金淋巴瘤的肿瘤细胞进行了Tac抗原检测。约四分之一的病例表达了Tac抗原，其中包括27%的B细胞系淋巴瘤、6%的T细胞系淋巴瘤以及四例Ki-1阳性淋巴瘤中的三例。Tac抗原表达发生率最高的B细胞系淋巴瘤是弥漫性和滤泡性大细胞淋巴瘤，约一半的病例表达了Tac抗原。除浆细胞瘤/骨髓瘤、小无裂细胞（伯基特氏和非伯基特氏）以及淋巴母细胞性恶性肿瘤外，所有主要类型的淋巴瘤均表达Tac抗原。
