UHRF1：表观遗传学的关键调节因子及癌症治疗的分子靶点。
UHRF1: The key regulator of epigenetics and molecular target for cancer therapeutics.
作者信息
Sidhu Harsimran, Capalash Neena
机构信息
Department of Biotechnology, Panjab University, Chandigarh, India.
出版信息
Tumour Biol. 2017 Feb;39(2):1010428317692205. doi: 10.1177/1010428317692205.
UHRF1 is a master regulator of epigenome as it coordinates DNA methylation and histone modifications. Compelling evidence suggests a strong link between UHRF1 overexpression and tumorigenesis, substantiating its ability to act as a potential biomarker for cancer diagnosis and prognosis. UHRF1 also mediates repair of damaged DNA that makes cancer cells resistant toward cytocidal drugs. Hence, understanding the molecular mechanism of UHRF1 regulation would help in developing cancer therapeutics. Natural compounds have shown applicability to downregulate UHRF1 leading to growth arrest and apoptosis in cancer cells.
UHRF1是表观基因组的主要调节因子，因为它协调DNA甲基化和组蛋白修饰。有力证据表明UHRF1过表达与肿瘤发生之间存在紧密联系，证实了其作为癌症诊断和预后潜在生物标志物的能力。UHRF1还介导受损DNA的修复，使癌细胞对杀伤性药物产生抗性。因此，了解UHRF1调控的分子机制将有助于开发癌症治疗方法。天然化合物已显示出可下调UHRF1，从而导致癌细胞生长停滞和凋亡。
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