Lerer B, Ebstein R P, Shestatsky M, Shemesh Z, Greenberg D
Jerusalem Mental Health Center-Ezrath Nashim, Israel.
Am J Psychiatry. 1987 Oct;144(10):1324-7. doi: 10.1176/ajp.144.10.1324.
Cyclic adenosine 3',5'-monophosphate (cAMP) signal transduction was examined in lymphocytes and platelets obtained from patients with posttraumatic stress disorder. Intact lymphocytes from the posttraumatic patients (N = 10) showed significantly lower basal, isoproterenol-, and forskolin-stimulated cAMP levels than those from 10 healthy control subjects. In platelet membrane preparations, basal, forskolin-, aluminum chloride plus sodium fluoride-, and prostaglandin E1-stimulated adenylate cyclase activity levels were all significantly lower in the posttraumatic group than in the control group. The authors discuss the potential role of their findings as a biological marker for posttraumatic stress disorder.
对创伤后应激障碍患者的淋巴细胞和血小板中的环磷酸腺苷（cAMP）信号转导进行了检测。创伤后患者（N = 10）的完整淋巴细胞显示，其基础、异丙肾上腺素和福司可林刺激后的cAMP水平显著低于10名健康对照受试者。在血小板膜制剂中，创伤后组的基础、福司可林、氯化铝加氟化钠以及前列腺素E1刺激后的腺苷酸环化酶活性水平均显著低于对照组。作者讨论了其研究结果作为创伤后应激障碍生物标志物的潜在作用。
