Li T, Miao W, He H G, Xian J F
Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Zhonghua Yi Xue Za Zhi. 2017 Feb 7;97(5):347-352. doi: 10.3760/cma.j.issn.0376-2491.2017.05.006.
To study the alteration of the optic radiations in patients with primary open-angle glaucoma (POAG) by diffusion tensor imaging (DTI) and tractography, and to reveal the correlation between the DTI derived parameters and the severity of the disease. A total of 24 patients with POAG and 20 age- and gender-matched healthy controls were enrolled in this study from January 2011 to June 2013.All subjects underwent ophthalmoscopy, standard automatic perimetry, intraocular pressure measurement and MRI scanning.All the eyes of POAG patients were evaluated by Hodapp-Anderson-Parrish (HAP) system.Then the stages of bilateral eyes were added together to evaluate the disease severity.Tractography was used to measure the fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD) of the optic radiations of these subjects.The results of the two groups were compared.Partial correlation was then used to reveal the correlation between these derived DTI parameters and the severity of POAG. Compared with health controls, POAG patients showed significant decreased FA (=-3.299, =0.002) and AD (=-2.485, =0.013), increased RD (=2.365, =0.018) in optic radiation .The alteration of MD was not significant (=0.719, =0.454). Mean FA values of the optic radiations were negatively correlated with POAG stages (=-0.643, = 0.001), while mean RD values (=0.570, = 0.004) and mean MD values (= 0.448, = 0.028) were positively correlated with POAG stages.No correlation between AD values and severity of POAG was found. In the optic radiations of POAG patients, the FA values and AD values decrease, while RD values increase, indicating the fiber integrity changes.The alterations of FA, RD and MD are correlated with disease severity.
采用弥散张量成像（DTI）及纤维束成像技术研究原发性开角型青光眼（POAG）患者视辐射的改变，并揭示DTI衍生参数与疾病严重程度之间的相关性。2011年1月至2013年6月，本研究共纳入24例POAG患者及20例年龄、性别匹配的健康对照者。所有受试者均接受眼科检查、标准自动视野计检查、眼压测量及MRI扫描。采用Hodapp-Anderson-Parrish（HAP）系统对POAG患者的所有患眼进行评估。然后将双眼的分期相加来评估疾病严重程度。采用纤维束成像技术测量这些受试者视辐射的各向异性分数（FA）、平均扩散率（MD）、径向扩散率（RD）和轴向扩散率（AD）。比较两组结果。然后采用偏相关分析揭示这些DTI衍生参数与POAG严重程度之间的相关性。与健康对照相比，POAG患者视辐射的FA（t=-3.299，P=0.002）和AD（t=-2.485，P=0.013）显著降低，RD升高（t=2.365，P=0.018）。MD的改变不显著（t=0.719，P=0.454）。视辐射的平均FA值与POAG分期呈负相关（r=-0.643，P=0.001），而平均RD值（r=0.570，P=0.004）和平均MD值（r=0.448，P=0.028）与POAG分期呈正相关。未发现AD值与POAG严重程度之间存在相关性。在POAG患者的视辐射中，FA值和AD值降低，而RD值升高，表明纤维完整性发生改变。FA、RD和MD的改变与疾病严重程度相关。
