Montes A, Fernández A, Camacho V, de Quintana C, Gallego O, Craven-Bartle J, López D, Molet J, Gómez-Ansón B, Carrió I
Servicio de Medicina Nuclear, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
Servicio de Medicina Nuclear, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
Rev Esp Med Nucl Imagen Mol. 2017 Jul-Aug;36(4):227-232. doi: 10.1016/j.remn.2016.11.005. Epub 2017 Feb 17.
To study the usefulness of F-fluorocholine (FCH) in detecting the recurrence of primary brain tumours.
A prospective study was conducted on brain PET/CT with FCH for compassionate use in 21 patients with suspected recurrence of a primary brain tumour. The distribution by pathology was: three grade ii astrocytomas, three grade iii astrocytomas, one grade ii oligodendroglioma, three grade iii oligodendrogliomas, one grade iii oligoastrocytoma, four glioblastoma multiform, one gliomatosis cerebri, and five meningiomas. Studies in which there was a visually significant uptake in the brain parenchyma were classified as positive.
A total of 17 patients were classified as positive, with the results being confirmed by histology (10 cases) or clinical follow-up and imaging, with no false positives or negatives. The mean SUVmax for positive patients was 8.02 and 0.94 for the negative ones, which was significantly different (P=.003) CONCLUSION: PET/CT with FCH shows encouraging results in the evaluation of patients with suspected recurrence of primary brain neoplasms.
研究F-氟胆碱（FCH）在检测原发性脑肿瘤复发中的作用。
对21例疑似原发性脑肿瘤复发的患者进行了一项前瞻性研究，使用FCH进行脑部PET/CT检查以用于同情用药。病理分布情况如下：3例二级星形细胞瘤、3例三级星形细胞瘤、1例二级少突胶质细胞瘤、3例三级少突胶质细胞瘤、1例三级少突星形细胞瘤、4例多形性胶质母细胞瘤、1例大脑胶质瘤病和5例脑膜瘤。脑实质出现明显可见摄取的检查被分类为阳性。
共有17例患者被分类为阳性，结果经组织学（10例）或临床随访及影像学证实，无假阳性或假阴性。阳性患者的平均SUVmax为8.02，阴性患者为0.94，差异有统计学意义（P = 0.003）。结论：FCH PET/CT在评估疑似原发性脑肿瘤复发的患者中显示出令人鼓舞的结果。
