Lam Winnie Wing-Chuen, Ng David Chee-Eng, Wong Wai Yin, Ong Seng Chuan, Yu Sidney Wing-Kwong, See Siew Ju
Department of Nuclear Medicine & PET, Singapore General Hospital, Singapore 169608, Singapore.
Clin Neurol Neurosurg. 2011 Feb;113(2):156-61. doi: 10.1016/j.clineuro.2010.09.012. Epub 2010 Oct 30.
Primary brain tumors (PBT), in particular gliomas, are among the most difficult neoplasms to treat, necessitating good quality imaging to guide clinicians at many junctures. Current imaging modalities, including [18F] fluorodeoxyglucose (FDG) PET/CT, MRI and MR spectroscopy (MRS), have various limitations, particularly with regard to differentiating tumor from radiation induced necrosis (RIN) and from normal cerebral metabolic uptake. [18F] fluorocholine (FCH) is an analog of choline with potentially optimal imaging characteristics, as pharmacokinetic studies with FCH conducted in patients showed minimal FCH uptake by normal brain parenchyma, whereas high-grade tumors are known to have increased choline uptake. We present two cases of our early experience with FCH PET/CT for patients with PBT and discuss the potential use and comparative limitations of this imaging modality.
原发性脑肿瘤（PBT），尤其是胶质瘤，是最难治疗的肿瘤之一，这就需要高质量的影像学检查在多个关键节点为临床医生提供指导。目前的影像学检查方法，包括[18F]氟脱氧葡萄糖（FDG）PET/CT、磁共振成像（MRI）和磁共振波谱（MRS），都有各种局限性，尤其是在区分肿瘤与放射性坏死（RIN）以及正常脑代谢摄取方面。[18F]氟胆碱（FCH）是胆碱的类似物，具有潜在的最佳成像特性，因为在患者中进行的FCH药代动力学研究显示，正常脑实质对FCH的摄取极少，而高级别肿瘤已知胆碱摄取增加。我们介绍了两例使用FCH PET/CT检查PBT患者的早期经验，并讨论了这种成像方式的潜在用途和相对局限性。
