Matskevichus Z K
Arkh Patol. 1987;49(6):3-10.
Three stages in collagen biodegradation are considered: intracellular post-translational degradation of normal procollagen prior to its extracellular secretion; specific enzymatic cleavage of collagen fibrils in the extracellular space; and unspecific proteolysis of the cleaved despiralized molecular fragments. Enzymes involved in collagen breakdown are described. The importance of collagen biodegradation to morphogenesis and morphostasis is discussed, as are its disturbances in a number of pathological conditions.
正常前胶原在细胞外分泌之前的细胞内翻译后降解；细胞外空间中胶原纤维的特异性酶解；以及裂解的解螺旋分子片段的非特异性蛋白水解。文中描述了参与胶原分解的酶。讨论了胶原生物降解对形态发生和形态稳定的重要性，以及它在一些病理状况下的紊乱情况。
