Jansen Petra Lynen, Klinge Uwe, Jansen Marc, Junge Karsten
Department of Surgery, University Hospital, RWTH Aachen, Germany.
BMC Surg. 2009 Dec 9;9:18. doi: 10.1186/1471-2482-9-18.
Family history, male gender and age are significant risk factors for inguinal hernia disease. Family history provides evidence for a genetic trait and could explain early recurrence after inguinal hernia repair despite technical advance at least in a subgroup of patients. This study evaluates if age and family history can be identified as risk factors for early recurrence after primary hernia repair.
We performed an observational cohort study for 75 patients having at least two recurrent hernias. The impact of age, gender and family history on the onset of primary hernias, age at first recurrence and recurrence rates was investigated.
44% (33/75) of recurrent hernia patients had a family history and primary as well as recurrent hernias occurred significantly earlier in this group (p = 0.04). The older the patients were at onset the earlier they got a recurrent hernia. Smoking could be identified as on additional risk factor for early onset of hernia disease but not for hernia recurrence.
Our data reveal an increased incidence of family history for recurrent hernia patients when compared with primary hernia patients. Patients with a family history have their primary hernias as well as their recurrence at younger age then patients without a family history. Though recurrent hernia has to be regarded as a disease caused by multiple factors, a family history may be considered as a criterion to identify the risk for recurrence before the primary operation.
家族史、男性性别和年龄是腹股沟疝疾病的重要危险因素。家族史为遗传特征提供了证据,并且至少在一部分患者中可以解释尽管技术进步但腹股沟疝修补术后的早期复发情况。本研究评估年龄和家族史是否可被确定为初次疝修补术后早期复发的危险因素。
我们对75例至少有两次复发性疝的患者进行了一项观察性队列研究。研究了年龄、性别和家族史对原发性疝发病、首次复发年龄和复发率的影响。
44%(33/75)的复发性疝患者有家族史,且该组原发性疝和复发性疝的发病明显更早(p = 0.04)。患者发病时年龄越大,出现复发性疝的时间越早。吸烟可被确定为疝疾病早期发病的另一个危险因素,但不是疝复发的危险因素。
我们的数据显示,与原发性疝患者相比,复发性疝患者的家族史发生率更高。有家族史的患者比没有家族史的患者原发性疝和复发疝的发病年龄更小。尽管复发性疝必须被视为一种由多种因素引起的疾病,但家族史可被视为在初次手术前识别复发风险的一个标准。