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一名孕妇患三阴性乳腺癌并伴有脑转移。

Triple-negative breast cancer with brain metastasis in a pregnant woman.

作者信息

Trinca Francisco, Inácio Mariana, Timóteo Teresa, Dinis Rui

机构信息

Department of Medical Oncology, Hospital do Espírito Santo de Évora EPE, Évora, Portugal.

Hospital da Luz, Lisboa, Portugal.

出版信息

BMJ Case Rep. 2017 Feb 20;2017:bcr2016218657. doi: 10.1136/bcr-2016-218657.

Abstract

A woman aged 35 years was diagnosed with triple-negative breast cancer in October 2012. During the investigation, it was discovered that she was pregnant, the patient decided to have an abortion. She was submitted to a radical modified mastectomy and adjuvant chemotherapy followed by adjuvant breast radiotherapy of the left breast. 2 months after the adjuvant treatment, she began to have headaches and dizziness. The cranial MRI (head MRI) showed brain metastasis. She was then treated with whole brain radiotherapy, stereotactic radiosurgery and concomitant temozolomide which resulted in complete response. 1.5 year later, she was able to get pregnant and gave birth to a baby without complications. The previous imaging reassessment performed in September 2016 shows no evidence of recurrent breast cancer.

摘要

一名35岁女性于2012年10月被诊断为三阴性乳腺癌。在检查过程中,发现她已怀孕,患者决定终止妊娠。她接受了改良根治性乳房切除术及辅助化疗,随后对左侧乳房进行了辅助性乳房放疗。辅助治疗2个月后,她开始出现头痛和头晕。头颅磁共振成像(头部MRI)显示有脑转移。随后她接受了全脑放疗、立体定向放射外科治疗并同时使用替莫唑胺,结果达到完全缓解。1.5年后,她成功怀孕并顺利产下一名婴儿,没有出现并发症。2016年9月进行的先前影像学重新评估显示没有复发性乳腺癌的迹象。

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Breast cancer brain metastases: the last frontier.乳腺癌脑转移:最后的前沿领域。
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Breast cancer in pregnancy: a literature review.妊娠期乳腺癌:文献综述
Breast Cancer Res Treat. 2008 Apr;108(3):333-8. doi: 10.1007/s10549-007-9616-6. Epub 2007 May 26.
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CNS metastases in breast cancer.乳腺癌的中枢神经系统转移
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